| Short Description : | Recombinant-Human Rap1A-His-Tag protein was developed from e.coli and has a target region of His-Tag. For use in research applications. |
| Applications: | SDS-PAGE |
| Host: | E.coli |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Concentration: | 0.25 mg/mL |
| Formulation: | Liquid in 20mM Tris-HCl buffer (pH 8.0) containing 40% Glycerol, 5mM DTT, 200mM NaCl |
| Storage Instruction: | For short term storage, keep at +2C to +8C for up to 1 week. For long term storage, aliquot and store at-20C, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | RAP1A |
| Gene ID: | 5906 |
| Uniprot ID: | RAP1A_HUMAN |
| Accession Number: | NP_001010935 |
| Immunogen: | Human |
| Immunogen Region: | 1-181aa |
| Immunogen Sequence: | MGSSHHHHHH SSGLVPRGSH MREYKLVVLG SGGVGKSALT VQFVQGIFVE KYDPTIEDSY RKQVEVDCQQ CMLEILDTAG TEQFTAMRDL YMKNGQGFAL VYSITAQSTF NDLQDLREQI LRVKDTEDVP MILVGNKCDL EDERVVGKEQ GQNLARQWCN CAFLESSAKS KINVNEIFYD LVRQINRKTP VEKKKPKKKS C |
| Function | Counteracts the mitogenic function of Ras, at least partly because it can interact with Ras GAPs and RAF in a competitive manner. Together with ITGB1BP1, regulates KRIT1 localization to microtubules and membranes. Plays a role in nerve growth factor (NGF)-induced neurite outgrowth. Plays a role in the regulation of embryonic blood vessel formation. Involved in the establishment of basal endothelial barrier function. Facilitates the progressive accumulation of CDH1 at mature desmosome junctions via cAMP-dependent signaling and its interaction with PKP3. May be involved in the regulation of the vascular endothelial growth factor receptor KDR expression at endothelial cell-cell junctions. |
| Protein Name | Ras-Related Protein Rap-1aC21kgG-22kGtp-Binding Protein Smg P21aRas-Related Protein Krev-1 |
| Database Links | Reactome: R-HSA-170968Reactome: R-HSA-170984Reactome: R-HSA-354192Reactome: R-HSA-354194Reactome: R-HSA-372708Reactome: R-HSA-381676Reactome: R-HSA-392517Reactome: R-HSA-5674135Reactome: R-HSA-6798695Reactome: R-HSA-6802946Reactome: R-HSA-6802948Reactome: R-HSA-6802952Reactome: R-HSA-6802955Reactome: R-HSA-8875555Reactome: R-HSA-9649948Reactome: R-HSA-9656223 |
| Cellular Localisation | Cell MembraneLipid-AnchorCytoplasmPerinuclear RegionCell JunctionEarly EndosomeRecruited From Early Endosome To Late Endosome Compartment After Nerve Growth Factor (Ngf) StimulationLocalized With Rapgef2 At Cell-Cell JunctionsColocalized With Rapgef2 In The Perinuclear Region |
| Alternative Protein Names | Ras-Related Protein Rap-1a proteinC21kg proteinG-22k proteinGtp-Binding Protein Smg P21a proteinRas-Related Protein Krev-1 proteinRAP1A proteinKREV1 protein |
Information sourced from Uniprot.org