Human RAB24 protein (Recombinant) (His-Tag) (STJP017372)

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STJP017372
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Short Description :Recombinant-Human RAB24-His-Tag protein was developed from e.coli and has a target region of His-Tag. For use in research applications.
Applications:SDS-PAGE
Host:E.coli
Note:STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Concentration:0.5 mg/mL
Formulation:Liquid in 20mM Tris-HCl buffer (pH 8.0) containing 2mM DTT, 30% Glycerol, 100mM NaCl, 1mM EDTA
Storage Instruction:For short term storage, keep at +2C to +8C for up to 1 week. For long term storage, aliquot and store at-20C, and avoid repeat freeze-thaw cycles.
Gene Symbol:RAB24
Gene ID:53917
Uniprot ID:RAB24_HUMAN
Accession Number:NP_570137
Immunogen:Human
Immunogen Region:1-203aa
Immunogen Sequence:MSGQRV DVKVVMLGKE YVGKTSLVER YVHDRFLVGP YQNTIGAAFV AKVMSVGDRT VTLGIWDTAG SERYEAMSRI YYRGAKAAIV CYDLTDSSSF ERAKFWVKEL RSLEEGCQIY LCGTKSDLLE EDRRRRRVDF HDVQDYADNI KAQLFETSSK TGQSVDELFQ KVAEDYVSVA AFQVMTEDKG VDLGQKPNPY FYSCCH
Post Translational Modifications Prenylated.prenylation is required for RAB24 localization to autophagosomes. Isoprenylation is inefficient compared to other Rab family members. Phosphorylated at Tyr-17 and Tyr-172. Cytosolic pool of RAB24 is more phosphorylated than the membrane-associated pool.
Function The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. RAB24 is an atypical RAB protein that presents low GTPase activity and thereby exists predominantly in the GTP-bound active state. RAB24 is required for the clearance of late autophagic vacuoles under basal conditions. It is not needed for starvation-induced autophagy. Involved in the modulation of meiotic apparatus assembly and meiotic progression during oocyte maturation, possibly through regulation of kinetochore-microtubule interaction.
Protein Name Ras-Related Protein Rab-24
Database Links Reactome: R-HSA-6798695
Reactome: R-HSA-8873719
Cellular Localisation Cytoplasm
Cytosol
Membrane
Lipid-Anchor
Cytoplasmic Vesicle
Autophagosome Membrane
Perinuclear Region
Cytoskeleton
Spindle
Only About 20% Is Recovered In The Particulate Fraction
Rab24 Localizes In Perinuclear Region And In The Limiting Membranes Of Autophagic Compartments Under Basal Conditions
Rab24 Is Localized In The Cytoplasm With An Accumulated Distribution In Nuclear Region At Germinal Vesicle (Gv) Stage Of Oocyte Meiotic Progression
At Pre-Metaphase I Stage
Localized In The Cytoplasm With A Particular Concentration Around Chromosomes
As The Oocytes Enter Metaphase I
Located To The Spindle Region
Similar Distribution Pattern Is Observed In Mii Oocytes
Alternative Protein Names Ras-Related Protein Rab-24 protein
RAB24 protein

Information sourced from Uniprot.org

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