Human RAB21 protein (Recombinant) (N-His) (STJP006192)
SPECIFICATIONS
HostE.coli
ImmunogenHomo sapiens (Human)
General Information
| Short Description | Recombinant-Human RAB21-N-His protein was developed from e.coli for the region N-His. For use in research applications. |
| Applications | ELISA/Immunogen/SDS-PAGE/WB |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Dilution Range | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| Formulation | Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol. |
| Storage Instruction | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt. |
Target Information
| Gene Symbol | RAB21 |
| Gene ID | 23011 |
| Uniprot ID | RAB21_HUMAN |
| Immunogen | Homo sapiens (Human) |
| Immunogen Region | Gly94-Ser217 |
Additional Info
| Function | The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. RAB21 is involved in membrane trafficking control. During the mitosis of adherent cells, controls the endosomal trafficking of integrins which is required for the successful completion of cytokinesis. Regulates integrin internalization and recycling, but does not influence the traffic of endosomally translocated receptors in general. As a result, may regulate cell adhesion and migration. Involved in neurite growth. Following SBF2/MTMT13-mediated activation in response to starvation-induced autophagy, binds to and regulates SNARE protein VAMP8 endolysosomal transport required for SNARE-mediated autophagosome-lysosome fusion. Modulates protein levels of the cargo receptors TMED2 and TMED10, and required for appropriate Golgi localization of TMED10. |
| Protein Name | Ras-Related Protein Rab-21 |
| Database Links | Reactome: R-HSA-8873719Reactome: R-HSA-8876198 |
| Cellular Localisation | Endoplasmic Reticulum MembraneLipid-AnchorGolgi ApparatusTrans-Golgi NetworkGolgi Apparatus MembraneEarly Endosome MembraneCytoplasmic Vesicle MembraneCleavage FurrowCell ProjectionNeuron ProjectionColocalizes With Ankrd27 And Vamp7 In NeuritesIn Nonpolarized Epithelial Caco-2 CellsFound In The Endoplasmic ReticulumIn Polarized CellsObserved In Vesicles In The Apical CytoplasmDuring MitosisIn Mid-TelophaseLocalized In The Ingressing Cleavage FurrowIn Late TelophaseDetected At The Opposite Poles Of The Daughter CellsIn Vesicles At The Base Of Lamellipodia Formed By The Separating Daughter Cells |
| Alternative Protein Names | Ras-Related Protein Rab-21 proteinRAB21 proteinKIAA0118 protein |
Information sourced from Uniprot.org