Human RAB21 protein (Recombinant) (N-His) (STJP006192)

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STJP006192
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Host: E. coli
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Recombinant-Human RAB21-N-His protein was developed from e. coli and has a target region of N-His. For use in research applications.
Formulation: Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Storage Instruction: Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt.
Gene Symbol: RAB21
Gene ID: 23011
Uniprot ID: RAB21_HUMAN
Immunogen Region: Gly94-Ser217
Immunogen: Homo sapiens (Human)
Function Small GTPase involved in membrane trafficking control. During the mitosis of adherent cells, controls the endosomal trafficking of integrins which is required for the successful completion of cytokinesis. Regulates integrin internalization and recycling, but does not influence the traffic of endosomally translocated receptors in general. As a result, may regulate cell adhesion and migration. Involved in neurite growth. Following SBF2/MTMT13-mediated activation in response to starvation-induced autophagy, binds to and regulates SNARE protein VAMP8 endolysosomal transport required for SNARE-mediated autophagosome-lysosome fusion. Modulates protein levels of the cargo receptors TMED2 and TMED10, and required for appropriate Golgi localization of TMED10.
Protein Name Ras-Related Protein Rab-21
Database Links Reactome: R-HSA-8873719
Reactome: R-HSA-8876198
Cellular Localisation Endoplasmic Reticulum Membrane
Lipid-Anchor
Golgi Apparatus
Trans-Golgi Network
Golgi Apparatus Membrane
Early Endosome Membrane
Cytoplasmic Vesicle Membrane
Cleavage Furrow
Cell Projection
Neuron Projection
Colocalizes With Ankrd27 And Vamp7 In Neurites
In Nonpolarized Epithelial Caco-2 Cells
Found In The Endoplasmic Reticulum
In Polarized Cells
Observed In Vesicles In The Apical Cytoplasm
During Mitosis
In Mid-Telophase
Localized In The Ingressing Cleavage Furrow
In Late Telophase
Detected At The Opposite Poles Of The Daughter Cells
In Vesicles At The Base Of Lamellipodia Formed By The Separating Daughter Cells
Alternative Protein Names Ras-Related Protein Rab-21 protein
RAB21 protein
KIAA0118 protein

Information sourced from Uniprot.org

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