• Human PVR/CD155 protein (Recombinant) (C-hFc&His) (STJP001080)
  • Human PVR/CD155 protein (Recombinant) (C-hFc&His) (STJP001080)
  • Human PVR/CD155 protein (Recombinant) (C-hFc&His) (STJP001080)
  • Human PVR/CD155 protein (Recombinant) (C-hFc&His) (STJP001080)

Human PVR/CD155 protein (Recombinant) (C-hFc&His) (STJP001080)

SKU:
STJP001080

£76.50 - £248.50
Current Stock:
Host: HEK293 cells
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Recombinant-Human PVR/CD155-C-hFc&His protein was developed from hek293 cells and has a target region of C-hFc&His. For use in research applications.
Formulation: Lyophilized from a 0.22 Mu m filtered solution of PBS, pH 7.4. Contact us for customized product form or formulation.
Immunoreactivity: Measured by its binding ability in a functional ELISA. Immobilized Human CD155 at 2 Mu g/mL (100 Mu L/well) can bind Human CD96 with a linear range of 0.1-76 ng/mL.
Gene Symbol: PVR
Gene ID: 5817
Uniprot ID: PVR_HUMAN
Immunogen: Recombinant Human PVR/CD155 Protein is produced by HEK293 expression system. The target protein is expressed with sequence (Asp28-Asn343) of human CD155/PVR (Accession #NP_006496.4) fused with an Fc, 6×His tag at the C-terminus.
Post Translational Modifications N-glycosylated. N-glycan at Asn-120: Hex5HexNAc4. Phosphorylated by Src kinases on tyrosine residues in the ITIM motif upon ligation. Interaction with TIGIT is required for Phosphorylation.
Function Mediates NK cell adhesion and triggers NK cell effector functions. Binds two different NK cell receptors: CD96 and CD226. These interactions accumulates at the cell-cell contact site, leading to the formation of a mature immunological synapse between NK cell and target cell. This may trigger adhesion and secretion of lytic granules and IFN-gamma and activate cytotoxicity of activated NK cells. May also promote NK cell-target cell modular exchange, and PVR transfer to the NK cell. This transfer is more important in some tumor cells expressing a lot of PVR, and may trigger fratricide NK cell activation, providing tumors with a mechanism of immunoevasion. Plays a role in mediating tumor cell invasion and migration. (Microbial infection) Acts as a receptor for poliovirus. May play a role in axonal transport of poliovirus, by targeting virion-PVR-containing endocytic vesicles to the microtubular network through interaction with DYNLT1. This interaction would drive the virus-containing vesicle to the axonal retrograde transport. (Microbial infection) Acts as a receptor for Pseudorabies virus. (Microbial infection) Is prevented to reach cell surface upon infection by Human cytomegalovirus /HHV-5, presumably to escape immune recognition of infected cell by NK cells.
Protein Name Poliovirus Receptor
Nectin-Like Protein 5
Necl-5
Cd Antigen Cd155
Database Links Reactome: R-HSA-198933
Reactome: R-HSA-420597
Cellular Localisation Isoform Alpha: Cell Membrane
Single-Pass Type I Membrane Protein
Isoform Delta: Cell Membrane
Isoform Beta: Secreted
Isoform Gamma: Secreted
Alternative Protein Names Poliovirus Receptor protein
Nectin-Like Protein 5 protein
Necl-5 protein
Cd Antigen Cd155 protein
PVR protein
PVS protein

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance