Human PTPRU protein (Recombinant) (N-His) (STJP006686)

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STJP006686
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Host: E. coli
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Recombinant-Human PTPRU-N-His protein was developed from e. coli and has a target region of N-His. For use in research applications.
Formulation: Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Storage Instruction: Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt.
Gene Symbol: PTPRU
Gene ID: 10076
Uniprot ID: PTPRU_HUMAN
Immunogen Region: Arg1263-Arg1446
Immunogen: Homo sapiens (Human)
Post Translational Modifications The extracellular domain is proteolytically processed through cleavage within the fibronectin type-III 4 domain. In addition to the 190 kDa full-length protein, proteolytic products of 100 kDa, 80 kDa and 73 kDa are observed. N-glycosylated. Phosphorylated on tyrosine residues upon activation of KIT with stem cell factor (SCF). The 73 kDa proteolytic product is not phosphorylated.
Function Tyrosine-protein phosphatase which dephosphorylates CTNNB1. Regulates CTNNB1 function both in cell adhesion and signaling. May function in cell proliferation and migration and play a role in the maintenance of epithelial integrity. May play a role in megakaryocytopoiesis.
Protein Name Receptor-Type Tyrosine-Protein Phosphatase U
R-Ptp-U
Pancreatic Carcinoma Phosphatase 2
Pcp-2
Protein-Tyrosine Phosphatase J
Ptp-J
Hptp-J
Protein-Tyrosine Phosphatase Pi
Ptp Pi
Protein-Tyrosine Phosphatase Receptor Omicron
Ptp-Ro
Receptor-Type Protein-Tyrosine Phosphatase Psi
R-Ptp-Psi
Database Links Reactome: R-HSA-1433557
Cellular Localisation Cell Junction
Cell Membrane
Single-Pass Type I Membrane Protein
Alternative Protein Names Receptor-Type Tyrosine-Protein Phosphatase U protein
R-Ptp-U protein
Pancreatic Carcinoma Phosphatase 2 protein
Pcp-2 protein
Protein-Tyrosine Phosphatase J protein
Ptp-J protein
Hptp-J protein
Protein-Tyrosine Phosphatase Pi protein
Ptp Pi protein
Protein-Tyrosine Phosphatase Receptor Omicron protein
Ptp-Ro protein
Receptor-Type Protein-Tyrosine Phosphatase Psi protein
R-Ptp-Psi protein
PTPRU protein
FMI protein
PCP2 protein
PTPRO protein

Information sourced from Uniprot.org

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