Human PTPRS protein (Recombinant) (N-His) (STJP005318)
SPECIFICATIONS
HostE.coli
ImmunogenHomo sapiens (Human)
General Information
| Short Description | Recombinant-Human PTPRS-N-His protein was developed from e.coli for the region N-His. For use in research applications. |
| Applications | ELISA/Immunogen/SDS-PAGE/WB |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Dilution Range | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| Formulation | Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol. |
| Storage Instruction | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt. |
Target Information
| Gene Symbol | PTPRS |
| Gene ID | 5802 |
| Uniprot ID | PTPRS_HUMAN |
| Immunogen | Homo sapiens (Human) |
| Immunogen Region | Arg77-Gly374 |
Additional Info
| Post Translational Modifications | A cleavage occurs, separating the extracellular domain from the transmembrane segment. This process called 'ectodomain shedding' is thought to be involved in receptor desensitization, signal transduction and/or membrane localization. |
| Function | Cell surface receptor that binds to glycosaminoglycans, including chondroitin sulfate proteoglycans and heparan sulfate proteoglycan. Binding to chondroitin sulfate and heparan sulfate proteoglycans has opposite effects on PTPRS oligomerization and regulation of neurite outgrowth. Contributes to the inhibition of neurite and axonal outgrowth by chondroitin sulfate proteoglycans, also after nerve transection. Plays a role in stimulating neurite outgrowth in response to the heparan sulfate proteoglycan GPC2. Required for normal brain development, especially for normal development of the pituitary gland and the olfactory bulb. Functions as a tyrosine phosphatase. Mediates dephosphorylation of NTRK1, NTRK2 and NTRK3. Plays a role in down-regulation of signaling cascades that lead to the activation of Akt and MAP kinases. Down-regulates TLR9-mediated activation of NF-kappa-B, as well as production of TNF, interferon alpha and interferon beta. |
| Protein Name | Receptor-Type Tyrosine-Protein Phosphatase SR-Ptp-SReceptor-Type Tyrosine-Protein Phosphatase SigmaR-Ptp-Sigma |
| Database Links | Reactome: R-HSA-3000178Reactome: R-HSA-388844Reactome: R-HSA-8849932Reactome: R-HSA-9034015 |
| Cellular Localisation | Cell MembraneSingle-Pass Type I Membrane ProteinCell ProjectionAxonPerikaryonCytoplasmic VesicleSecretory VesicleSynaptic Vesicle MembraneSynapseSynaptosomePostsynaptic DensityNeuron ProjectionGrowth ConeIs Rapidly Internalized When Dendritic Cells Are Stimulated With The Tlr9 Ligand Cytidine-Phosphate-Guanosine (Cpg)Detected In A Punctate Pattern Along Neurites And Axon Growth Cones |
| Alternative Protein Names | Receptor-Type Tyrosine-Protein Phosphatase S proteinR-Ptp-S proteinReceptor-Type Tyrosine-Protein Phosphatase Sigma proteinR-Ptp-Sigma proteinPTPRS protein |
Information sourced from Uniprot.org