Human PTPRQ protein (Recombinant) (N-His) (STJP010062)

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STJP010062
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Host: E. coli
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Recombinant-Human PTPRQ-N-His protein was developed from e. coli and has a target region of N-His. For use in research applications.
Formulation: Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Storage Instruction: Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt.
Gene Symbol: PTPRQ
Uniprot ID: PTPRQ_HUMAN
Immunogen Region: Arg1929-Asn2070
Immunogen: Homo sapiens (Human)
Function Dephosphorylates phosphatidylinositol phosphates, such as phosphatidylinositol 3,4,5-trisphosphate (PIP3) and phosphatidylinositol 3,5-diphosphates, with preference for PIP3. Phosphate can be hydrolyzed from the D3 and D5 positions in the inositol ring. Has low tyrosine-protein phosphatase activity.however, the relevance of such activity in vivo is unclear. Plays an important role in adipogenesis of mesenchymal stem cells (MSCs). Regulates the phosphorylation state of AKT1 by regulating the levels of PIP3 in MSCs and preadipocyte cells. May act by regulating the level of phosphatidylinositol 4,5-bisphosphate (PIP2) level in the basal region of hair bundles. Required for auditory function.
Protein Name Phosphatidylinositol Phosphatase Ptprq
Receptor-Type Tyrosine-Protein Phosphatase Q
Ptp-Rq
R-Ptp-Q
Cellular Localisation Cell Projection
Stereocilium
Apical Cell Membrane
Single-Pass Type I Membrane Protein
Basal Cell Membrane
Detected At The Stereocilium Base And At The Apical Cell Membrane In Mature Hair Cells
Forms Ring-Like Structures In The Stereocilium Taper Region
Detected At The Basal Cell Membrane In Fetal Kidney Podocytes
Alternative Protein Names Phosphatidylinositol Phosphatase Ptprq protein
Receptor-Type Tyrosine-Protein Phosphatase Q protein
Ptp-Rq protein
R-Ptp-Q protein
PTPRQ protein

Information sourced from Uniprot.org