| Function | Dephosphorylates phosphatidylinositol phosphates, such as phosphatidylinositol 3,4,5-trisphosphate (PIP3) and phosphatidylinositol 3,5-diphosphates, with preference for PIP3. Phosphate can be hydrolyzed from the D3 and D5 positions in the inositol ring. Has low tyrosine-protein phosphatase activity in vitro.however, the relevance of such activity in vivo is unclear. Plays an important role in adipogenesis of mesenchymal stem cells (MSCs). Regulates the phosphorylation state of AKT1 by regulating the levels of PIP3 in MSCs and preadipocyte cells. Required for hair bundle maturation, a process that enables hair cells to detect and transmit sound and balance signals effectively, therefore affecting auditory function. May act by regulating the level of phosphatidylinositol 4,5-bisphosphate (PIP2) level in the basal region of hair bundles. |
| Protein Name | Phosphatidylinositol Phosphatase Ptprq Receptor-Type Tyrosine-Protein Phosphatase QPtp-RqR-Ptp-Q |
| Cellular Localisation | Cell ProjectionStereociliumApical Cell MembraneSingle-Pass Type I Membrane ProteinBasal Cell MembraneDetected At The Stereocilium Base And At The Apical Cell Membrane In Mature Hair CellsForms Ring-Like Structures In The Stereocilium Taper RegionDetected At The Basal Cell Membrane In Fetal Kidney Podocytes |
| Alternative Protein Names | Phosphatidylinositol Phosphatase Ptprq proteinReceptor-Type Tyrosine-Protein Phosphatase Q proteinPtp-Rq proteinR-Ptp-Q proteinPTPRQ protein |
Information sourced from Uniprot.org
