Human PTK7/CCK4 protein (Recombinant) (C-His) (STJP002322)
SPECIFICATIONS
HostHEK293 cells
ConjugationUnconjugated
ImmunogenRecombinant Human PTK7/CCK4 Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Ala31-Thr704) of human PTK7/CCK4 (Accession #Q13308) fused with a His tag at the C-terminus.
General Information
| Short Description | Recombinant-Human PTK7/CCK4-C-His protein was developed in hek293 cells using the region Ala31-Thr704. For use in research applications. |
| Host | HEK293 cells |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Conjugation | Unconjugated |
| Formulation | Lyophilised from a 0.22 Mu m filtered solution of PBS, pH 7.4. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Determination Method | < 0.1 EU/Mu g |
Target Information
| Gene Symbol | PTK7 |
| Gene ID | 5754 |
| Uniprot ID | PTK7_HUMAN |
| Immunogen | Recombinant Human PTK7/CCK4 Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Ala31-Thr704) of human PTK7/CCK4 (Accession #Q13308) fused with a His tag at the C-terminus. |
| Immunogen Region | Ala31-Thr704 |
| Immunogen Sequence | AIVFIKQPSSQDALQGRRAL LRCEVEAPGPVHVYWLLDGA PVQDTERRFAQGSSLSFAAV DRLQDSGTFQCVARDDVTGE EARSANASFNIKWIEAGPVV LKHPASEAEIQPQTQVTLRC HIDGHPRPTYQWFRDGTPLS DGQSNHTVSSKERNLTLRPA GPEHSGLYSCCAHSAFGQAC SSQNFTLSIADESFARVVLA PQDVVVARYEEAMFHCQFSA QPPPSLQWLFEDETPITNR |
Additional Info
| Post Translational Modifications | MMP14 cleaves PTK7 between Pro-621 and Leu-622 generating an N-terminal soluble (70 kDa) fragment and a membrane C-terminal (50 kDa) fragment. Proteolysis by MMP14 regulates PTK7 function in non-canonical Wnt signaling pathway. |
| Function | Inactive tyrosine kinase involved in Wnt signaling pathway. Component of both the non-canonical (also known as the Wnt/planar cell polarity signaling) and the canonical Wnt signaling pathway. Functions in cell adhesion, cell migration, cell polarity, proliferation, actin cytoskeleton reorganization and apoptosis. Has a role in embryogenesis, epithelial tissue organization and angiogenesis. |
| Protein Name | Inactive Tyrosine-Protein Kinase 7Colon Carcinoma Kinase 4Cck-4Protein-Tyrosine Kinase 7Pseudo Tyrosine Kinase Receptor 7Tyrosine-Protein Kinase-Like 7 |
| Database Links | |
| Cellular Localisation | MembraneSingle-Pass Type I Membrane ProteinCell JunctionColocalizes With Mmp14 At Cell JunctionsAlso Localizes At The Leading Edge Of Migrating Cells |
| Alternative Protein Names | Inactive Tyrosine-Protein Kinase 7 proteinColon Carcinoma Kinase 4 proteinCck-4 proteinProtein-Tyrosine Kinase 7 proteinPseudo Tyrosine Kinase Receptor 7 proteinTyrosine-Protein Kinase-Like 7 proteinPTK7 proteinCCK4 protein |
Information sourced from Uniprot.org