Human PTK7/CCK-4 protein (Recombinant) (C-His) (STJP007093)

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STJP007093
€586.88 - €3,115.63
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Host: Mammalian Cells
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Recombinant-Human PTK7/CCK-4-C-His protein was developed from mammalian cells and has a target region of C-His. For use in research applications.
Formulation: Lyophilized from a solution in PBS pH 7.4, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Storage Instruction: Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt.
Gene Symbol: PTK7
Gene ID: 5754
Uniprot ID: PTK7_HUMAN
Immunogen Region: Met1-Thr704
Immunogen: Homo sapiens (Human)
Post Translational Modifications MMP14 cleaves PTK7 between Pro-621 and Leu-622 generating an N-terminal soluble (70 kDa) fragment and a membrane C-terminal (50 kDa) fragment. Proteolysis by MMP14 regulates PTK7 function in non-canonical Wnt signaling pathway.
Function Inactive tyrosine kinase involved in Wnt signaling pathway. Component of both the non-canonical (also known as the Wnt/planar cell polarity signaling) and the canonical Wnt signaling pathway. Functions in cell adhesion, cell migration, cell polarity, proliferation, actin cytoskeleton reorganization and apoptosis. Has a role in embryogenesis, epithelial tissue organization and angiogenesis.
Protein Name Inactive Tyrosine-Protein Kinase 7
Colon Carcinoma Kinase 4
Cck-4
Protein-Tyrosine Kinase 7
Pseudo Tyrosine Kinase Receptor 7
Tyrosine-Protein Kinase-Like 7
Cellular Localisation Membrane
Single-Pass Type I Membrane Protein
Cell Junction
Colocalizes With Mmp14 At Cell Junctions
Also Localizes At The Leading Edge Of Migrating Cells
Alternative Protein Names Inactive Tyrosine-Protein Kinase 7 protein
Colon Carcinoma Kinase 4 protein
Cck-4 protein
Protein-Tyrosine Kinase 7 protein
Pseudo Tyrosine Kinase Receptor 7 protein
Tyrosine-Protein Kinase-Like 7 protein
PTK7 protein
CCK4 protein

Information sourced from Uniprot.org

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