| Tissue Specificity | |
| Post Translational Modifications | Phosphorylated by MAP3K3. Phosphorylation at Ser-247 promotes its association with CCAR2. Acetylation at the major site Lys-195 is important for oligomerization and ability to degrade its target substrates. Deacetylated by SIRT1. |
| Function | Subunit of the 11S REG-gamma (also called PA28-gamma) proteasome regulator, a doughnut-shaped homoheptamer which associates with the proteasome. 11S REG-gamma activates the trypsin-like catalytic subunit of the proteasome but inhibits the chymotrypsin-like and postglutamyl-preferring (PGPH) subunits. Facilitates the MDM2-p53/TP53 interaction which promotes ubiquitination- and MDM2-dependent proteasomal degradation of p53/TP53, limiting its accumulation and resulting in inhibited apoptosis after DNA damage. May also be involved in cell cycle regulation. Mediates CCAR2 and CHEK2-dependent SIRT1 inhibition. |
| Protein Name | Proteasome Activator Complex Subunit 311s Regulator Complex Subunit GammaReg-GammaActivator Of Multicatalytic Protease Subunit 3Ki Nuclear AutoantigenProteasome Activator 28 Subunit GammaPa28gPa28gamma |
| Database Links | Reactome: R-HSA-9907900 |
| Cellular Localisation | NucleusCytoplasmLocalizes To The Cytoplasm During Mitosis Following Nuclear Envelope Breakdown At This Distinct Stage Of The Cell Cycle Which Allows Its Interaction With Map3k3 Kinase |
| Alternative ELISA Names | Proteasome Activator Complex Subunit 3 ELISA kit11s Regulator Complex Subunit Gamma ELISA kitReg-Gamma ELISA kitActivator Of Multicatalytic Protease Subunit 3 ELISA kitKi Nuclear Autoantigen ELISA kitProteasome Activator 28 Subunit Gamma ELISA kitPa28g ELISA kitPa28gamma ELISA kitPSME3 ELISA kit |
| output | |
Information sourced from Uniprot.org
