Human PSMA/FOLH1 protein (Recombinant) (N-hFc) (STJP002392)
SPECIFICATIONS
HostHEK293 cells
ConjugationUnconjugated
ImmunogenRecombinant Human PSMA/FOLH1 Protein is expressed from Expi293 with hFc tag at the N-terminal.；It contains Lys44-Ala750.
General Information
| Short Description | Recombinant-Human PSMA/FOLH1-N-hFc protein was developed in hek293 cells using the region Lys44-Ala750. For use in research applications. |
| Host | HEK293 cells |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Conjugation | Unconjugated |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Determination Method | <0.01 EU/ug of the protein by LAL method. |
Target Information
| Gene Symbol | FOLH1 |
| Gene ID | 2346 |
| Uniprot ID | FOLH1_HUMAN |
| Immunogen | Recombinant Human PSMA/FOLH1 Protein is expressed from Expi293 with hFc tag at the N-terminal.；It contains Lys44-Ala750. |
| Immunogen Region | Lys44-Ala750 |
Additional Info
| Post Translational Modifications | The first two amino acids at the N-terminus of isoform PSMA' appear to be cleaved by limited proteolysis. The N-terminus is blocked. |
| Function | Has both folate hydrolase and N-acetylated-alpha-linked-acidic dipeptidase (NAALADase) activity. Has a preference for tri-alpha-glutamate peptides. In the intestine, required for the uptake of folate. In the brain, modulates excitatory neurotransmission through the hydrolysis of the neuropeptide, N-aceylaspartylglutamate (NAAG), thereby releasing glutamate. Involved in prostate tumor progression. Also exhibits a dipeptidyl-peptidase IV type activity. In vitro, cleaves Gly-Pro-AMC. |
| Protein Name | Glutamate Carboxypeptidase 2Cell Growth-Inhibiting Gene 27 ProteinFolate Hydrolase 1Folylpoly-Gamma-Glutamate CarboxypeptidaseFgcpGlutamate Carboxypeptidase IiGcpiiMembrane Glutamate CarboxypeptidaseMgcpN-Acetylated-Alpha-Linked Acidic Dipeptidase INaaladase IProstate-Specific Membrane AntigenPsmPsmaPteroylpoly-Gamma-Glutamate Carboxypeptidase |
| Database Links | Reactome: R-HSA-8963693 |
| Cellular Localisation | Cell MembraneSingle-Pass Type Ii Membrane ProteinIsoform Psma': Cytoplasm |
| Alternative Protein Names | Glutamate Carboxypeptidase 2 proteinCell Growth-Inhibiting Gene 27 Protein proteinFolate Hydrolase 1 proteinFolylpoly-Gamma-Glutamate Carboxypeptidase proteinFgcp proteinGlutamate Carboxypeptidase Ii proteinGcpii proteinMembrane Glutamate Carboxypeptidase proteinMgcp proteinN-Acetylated-Alpha-Linked Acidic Dipeptidase I proteinNaaladase I proteinProstate-Specific Membrane Antigen proteinPsm proteinPsma proteinPteroylpoly-Gamma-Glutamate Carboxypeptidase proteinFOLH1 proteinFOLH proteinNAALAD1 proteinPSM proteinPSMA proteinGIG27 protein |
Information sourced from Uniprot.org