Human PRTN3 protein (Recombinant) (C-His) (STJP013261)

Name: Human PRTN3 protein (Recombinant) (C-His) (STJP013261)
SKU: STJP013261-100
Price: 503.5 GBP
Availability: InStock

⇓ Datasheet ⇓ SDS

SPECIFICATIONS

HostMammalian Cells

ConjugationUnconjugated

ImmunogenHomo sapiens (Human)

STJP013261-100

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Short Description	Recombinant-Human PRTN3-C-His protein was developed from mammalian cells and has a target region of C-His. For use in research applications.
Applications	ELISA/WB
Host	Mammalian Cells
Note	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.

Conjugation	Unconjugated
Formulation	Supplied as a 0.22 Mu m filtered solution in 10mM Tris-HCl, 150mM NaCl, 10% Glycerol, pH 8.0.
Storage Instruction	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for one week. Store at-20 to-80°C for twelve months from the date of receipt.
Endotoxin	< 1 EU/µg as determined by LAL test.

Function	Serine protease that degrades elastin, fibronectin, laminin, vitronectin, and collagen types I, III, and IV (in vitro). By cleaving and activating receptor F2RL1/PAR-2, enhances endothelial cell barrier function and thus vascular integrity during neutrophil transendothelial migration. Plays a role in neutrophil transendothelial migration, probably when associated with CD177. Triggers inflammatory processes in neutrophils by interacting with ADGRG3 upstream of F2RL1/PAR2 activation.
Protein Name	Myeloblastin Agp7 C-Anca Antigen Leukocyte Proteinase 3 Pr-3 Pr3 Neutrophil Proteinase 4 Np-4 P29 Wegener Autoantigen
Database Links	Reactome: R-HSA-140875 Reactome: R-HSA-449836 Reactome: R-HSA-6798695 Reactome: R-HSA-6803157
Cellular Localisation	Cytoplasmic Granule Secreted Cell Membrane Peripheral Membrane Protein Extracellular Side Membrane Raft Localizes Predominantly To Azurophil Granules (Primary Secretory Granules) In Neutrophils Secreted Upon Neutrophil Stimulation By Tnf-Alpha Lipopolysaccharide (Lps) Fmlp And Cxcl8/Il8 Or During Neutrophil Transmigration Following Secretion Tethered To The Cell Membrane By Cd177
Alternative Protein Names	Myeloblastin protein Agp7 protein C-Anca Antigen protein Leukocyte Proteinase 3 protein Pr-3 protein Pr3 protein Neutrophil Proteinase 4 protein Np-4 protein P29 protein Wegener Autoantigen protein PRTN3 protein MBN protein

Information sourced from Uniprot.org