Human PRPH protein (Recombinant) (N-His) (STJP008503)

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STJP008503
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Host: E. coli
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Recombinant-Human PRPH-N-His protein was developed from e. coli and has a target region of N-His. For use in research applications.
Formulation: Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Storage Instruction: Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt.
Gene Symbol: PRPH
Gene ID: 5630
Uniprot ID: PERI_HUMAN
Immunogen Region: Leu86-Val411
Immunogen: Homo sapiens (Human)
Post Translational Modifications Phosphorylated.phosphorylation increases after nerve injury in regenerating neurons.
Function Class-III neuronal intermediate filament protein. May form an independent structural network without the involvement of other neurofilaments or may cooperate with the neuronal intermediate filament proteins NEFL, NEFH, NEFM and INA to form a filamentous network. Assembly of the neuronal intermediate filaments may be regulated by RAB7A. Plays a role in the development of unmyelinated sensory neurons. May be involved in axon elongation and axon regeneration after injury. Inhibits neurite extension in type II spiral ganglion neurons in the cochlea.
Protein Name Peripherin
Neurofilament 4
Cellular Localisation Cytoplasm
Cytoskeleton
Cell Projection
Axon
Perikaryon
Alternative Protein Names Peripherin protein
Neurofilament 4 protein
PRPH protein
NEF4 protein
PRPH1 protein

Information sourced from Uniprot.org

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