Human PRPF8 protein (Recombinant) (N-His) (STJP008124)

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STJP008124
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Host: E. coli
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Recombinant-Human PRPF8-N-His protein was developed from e. coli and has a target region of N-His. For use in research applications.
Formulation: Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Storage Instruction: Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt.
Gene Symbol: PRPF8
Gene ID: 10594
Uniprot ID: PRP8_HUMAN
Immunogen Region: Thr2071-Ala2335
Immunogen: Homo sapiens (Human)
Function Plays a role in pre-mRNA splicing as core component of precatalytic, catalytic and postcatalytic spliceosomal complexes, both of the predominant U2-type spliceosome and the minor U12-type spliceosome. Functions as a scaffold that mediates the ordered assembly of spliceosomal proteins and snRNAs. Required for the assembly of the U4/U6-U5 tri-snRNP complex, a building block of the spliceosome. Functions as a scaffold that positions spliceosomal U2, U5 and U6 snRNAs at splice sites on pre-mRNA substrates, so that splicing can occur. Interacts with both the 5' and the 3' splice site.
Protein Name Pre-Mrna-Processing-Splicing Factor 8
220 Kda U5 Snrnp-Specific Protein
Prp8 Homolog
Splicing Factor Prp8
P220
Database Links Reactome: R-HSA-72163
Reactome: R-HSA-72165
Cellular Localisation Nucleus
Nucleus Speckle
Alternative Protein Names Pre-Mrna-Processing-Splicing Factor 8 protein
220 Kda U5 Snrnp-Specific Protein protein
Prp8 Homolog protein
Splicing Factor Prp8 protein
P220 protein
PRPF8 protein
PRPC8 protein

Information sourced from Uniprot.org

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