Human Prostaglandin E synthase 2/PTGES2 protein (Recombinant) (His-Tag) (STJP017194)

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STJP017194
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Host: E.coli
Applications: SDS-PAGE
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Recombinant-Human Prostaglandin E synthase 2/PTGES2-His-Tag protein was developed from e.coli and has a target region of His-Tag. For use in research applications.
Formulation: Liquid in 20mM Tris-HCl buffer (pH 8.0) containing 20% Glycerol, 2mM DTT, 0.2M NaCl, 0.1mM PMSF
Concentration: 0.5 mg/mL
Storage Instruction: For short term storage, keep at +2C to +8C for up to 1 week. For long term storage, aliquot and store at-20C, and avoid repeat freeze-thaw cycles.
Gene Symbol: PTGES2
Gene ID: 80142
Uniprot ID: PGES2_HUMAN
Immunogen Region: 1-186aa
Accession Number: NP_945176
Immunogen: Human
Immunogen Sequence: MGSSHHHHHH SSGLVPRGSH MKAVNEQGKE VTEFGNKYWL MLNEKEAQQV YGGKEARTEE MKWRQWADDW LVHLISPNVY RTPTEALASF DYIVREGKFG AVEGAVAKYM GAAAMYLISK RLKSRHRLQD NVREDLYEAA DKWVAAVGKD RPFMGGQKPN LADLAVYGVL RVMEGLDAFD DLMQHTHIQP WYLRVERAIT EASPAH
Tissue Specificity Widely expressed. Expressed in the heart, including apex, inter-ventricular septum, both atria and ventricles, but not in the aorta. Also expressed in fetal heart. Detected in various regions of the brain: cerebellum.occipital, frontal and parietal lobes. Also expressed in the lymph nodes, skeletal muscle, kidney and trachea, but not in the thymus or lung. Overexpressed in colorectal cancer.
Post Translational Modifications Synthesized as a Golgi membrane-associated protein, and the proteolytic removal of the N-terminal hydrophobic domain leads to the formation of a mature cytosolic enzyme.
Function Isomerase that catalyzes the conversion of PGH2 into the more stable prostaglandin E2 (PGE2) (in vitro). The biological function and the GSH-dependent property of PTGES2 is still under debate. In vivo, PTGES2 could form a complex with GSH and heme and would not participate in PGE2 synthesis but would catalyze the degradation of prostaglandin E2 H2 (PGH2) to 12(S)-hydroxy-5(Z),8(E),10(E)-heptadecatrienoic acid (HHT) and malondialdehyde (MDA).
Protein Name Prostaglandin E Synthase 2
Membrane-Associated Prostaglandin E Synthase-2
Mpge Synthase-2
Microsomal Prostaglandin E Synthase 2
Mpges-2
Prostaglandin-H(2 E-Isomerase Cleaved Into - Prostaglandin E Synthase 2 Truncated Form
Database Links Reactome: R-HSA-2162123
Reactome: R-HSA-6798695
Cellular Localisation Golgi Apparatus Membrane
Single-Pass Membrane Protein
Prostaglandin E Synthase 2 Truncated Form: Cytoplasm
Perinuclear Region
Synthesized As A Golgi Membrane-Bound Protein
Which Is Further Cleaved Into The Predominant Soluble Truncated Form
The Truncated Form Is Cytoplasmic And Is Enriched In The Perinuclear Region
Alternative Protein Names Prostaglandin E Synthase 2 protein
Membrane-Associated Prostaglandin E Synthase-2 protein
Mpge Synthase-2 protein
Microsomal Prostaglandin E Synthase 2 protein
Mpges-2 protein
Prostaglandin-H(2 E-Isomerase Cleaved Into - Prostaglandin E Synthase 2 Truncated Form protein
PTGES2 protein
C9orf15 protein
PGES2 protein

Information sourced from Uniprot.org

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