Human Profilin 1/PFN1 protein (Recombinant) (No-Tag) (STJP016518)

Name: Human Profilin 1/PFN1 protein (Recombinant) (No-Tag) (STJP016518)
SKU: STJP016518
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⇓ Datasheet ⇓ SDS

SPECIFICATIONS

HostE.coli

ImmunogenHuman

STJP016518

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Short Description	Recombinant-Human Profilin 1/PFN1-No-Tag protein was developed from e.coli and has a target region of No-Tag. For use in research applications.
Applications	SDS-PAGE
Host	E.coli
Note	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.

Concentration	1 mg/mL
Formulation	Liquid in 20mM Tris-HCl buffer (pH 8.0) containing 10% Glycerol
Storage Instruction	For short term storage, keep at +2C to +8C for up to 1 week. For long term storage, aliquot and store at-20C, and avoid repeat freeze-thaw cycles.
Endotoxin	< 1 EU per 1ug of protein (determined by LAL method)

Gene Symbol	PFN1
Gene ID	5216
Uniprot ID	PROF1_HUMAN
Accession Number	NP_005013
Immunogen	Human
Immunogen Region	1-140aa
Immunogen Sequence	MAGWNAYIDN LMADGTCQDA AIVGYKDSPS VWAAVPGKTF VNITPAEVGV LVGKDRSSFY VNGLTLGGQK CSVIRDSLLQ DGEFSMDLRT KSTGGAPTFN VTVTKTDKTL VLLMGKEGVH GGLINKKCYE MASHLRRSQY

Tissue Specificity	Expressed in epididymis (at protein level).
Post Translational Modifications	Phosphorylation at Ser-138 reduces its affinity for G-actin and blocks its interaction with HTT, reducing its ability to inhibit androgen receptor (AR) and HTT aggregation.
Function	Binds to actin and affects the structure of the cytoskeleton. At high concentrations, profilin prevents the polymerization of actin, whereas it enhances it at low concentrations. By binding to PIP2, it inhibits the formation of IP3 and DG. Inhibits androgen receptor (AR) and HTT aggregation and binding of G-actin is essential for its inhibition of AR.
Protein Name	Profilin-1 Epididymis Tissue Protein Li 184a Profilin I
Database Links	Reactome: R-HSA-114608 Reactome: R-HSA-376176 Reactome: R-HSA-4086400 Reactome: R-HSA-5663220
Cellular Localisation	Cytoplasm Cytoskeleton
Alternative Protein Names	Profilin-1 protein Epididymis Tissue Protein Li 184a protein Profilin I protein PFN1 protein

Information sourced from Uniprot.org