Human Profilin 1/PFN1 protein (Recombinant) (No-Tag) (STJP016518)

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STJP016518
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Host: E.coli
Applications: SDS-PAGE
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Recombinant-Human Profilin 1/PFN1-No-Tag protein was developed from e.coli and has a target region of No-Tag. For use in research applications.
Formulation: Liquid in 20mM Tris-HCl buffer (pH 8.0) containing 10% Glycerol
Concentration: 1 mg/mL
Storage Instruction: For short term storage, keep at +2C to +8C for up to 1 week. For long term storage, aliquot and store at-20C, and avoid repeat freeze-thaw cycles.
Endotoxin: < 1 EU per 1ug of protein (determined by LAL method)
Gene Symbol: PFN1
Gene ID: 5216
Uniprot ID: PROF1_HUMAN
Immunogen Region: 1-140aa
Accession Number: NP_005013
Immunogen: Human
Immunogen Sequence: MAGWNAYIDN LMADGTCQDA AIVGYKDSPS VWAAVPGKTF VNITPAEVGV LVGKDRSSFY VNGLTLGGQK CSVIRDSLLQ DGEFSMDLRT KSTGGAPTFN VTVTKTDKTL VLLMGKEGVH GGLINKKCYE MASHLRRSQY
Tissue Specificity Expressed in epididymis (at protein level).
Post Translational Modifications Phosphorylation at Ser-138 reduces its affinity for G-actin and blocks its interaction with HTT, reducing its ability to inhibit androgen receptor (AR) and HTT aggregation.
Function Binds to actin and affects the structure of the cytoskeleton. At high concentrations, profilin prevents the polymerization of actin, whereas it enhances it at low concentrations. By binding to PIP2, it inhibits the formation of IP3 and DG. Inhibits androgen receptor (AR) and HTT aggregation and binding of G-actin is essential for its inhibition of AR.
Protein Name Profilin-1
Epididymis Tissue Protein Li 184a
Profilin I
Database Links Reactome: R-HSA-114608
Reactome: R-HSA-376176
Reactome: R-HSA-4086400
Reactome: R-HSA-5663220
Cellular Localisation Cytoplasm
Cytoskeleton
Alternative Protein Names Profilin-1 protein
Epididymis Tissue Protein Li 184a protein
Profilin I protein
PFN1 protein

Information sourced from Uniprot.org

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