Human PRL-3/PTP4A3 protein (Recombinant) (His-Tag) (STJP016540)
SPECIFICATIONS
HostE.coli
ImmunogenHuman
General Information
| Short Description | Recombinant-Human PRL-3/PTP4A3-His-Tag protein was developed from e.coli and has a target region of His-Tag. For use in research applications. |
| Applications | SDS-PAGE |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Concentration | 1 mg/mL |
| Formulation | Liquid in 20mM Tris-HCl buffer (pH 8.0) containing 2mM EDTA, 1mM DTT, 10% Glycerol |
| Storage Instruction | For short term storage, keep at +2C to +8C for up to 1 week. For long term storage, aliquot and store at-20C, and avoid repeat freeze-thaw cycles. |
| Endotoxin | < 1 EU per 1ug of protein (determined by LAL method) |
Target Information
| Gene Symbol | PTP4A3 |
| Gene ID | 11156 |
| Uniprot ID | TP4A3_HUMAN |
| Accession Number | NP_116000 |
| Immunogen | Human |
| Immunogen Region | 1-173aa |
| Immunogen Sequence | MGSSHHHHHH SSGLVPRGSH MARMNRPAPV EVSYKHMRFL ITHNPTNATL STFIEDLKKY GATTVVRVCE VTYDKTPLEK DGITVVDWPF DDGAPPPGKV VEDWLSLVKA KFCEAPGSCV AVHCVAGLGR APVLVALALI ESGMKYEDAI QFIRQKRRGA INSKQLTYLE KYRPKQRLRF KDPHTHKTRC CVM |
Additional Info
| Tissue Specificity | Mainly expressed in cardiomyocytes and skeletal muscle.also found in pancreas. Consistently overexpressed in colon cancer metastasis. |
| Post Translational Modifications | Farnesylated. Farnesylation is required for membrane targeting. |
| Function | Protein tyrosine phosphatase which stimulates progression from G1 into S phase during mitosis. Enhances cell proliferation, cell motility and invasive activity, and promotes cancer metastasis. May be involved in the progression of cardiac hypertrophy by inhibiting intracellular calcium mobilization in response to angiotensin II. |
| Protein Name | Protein Tyrosine Phosphatase Type Iva 3Prl-RProtein-Tyrosine Phosphatase 4a3Protein-Tyrosine Phosphatase Of Regenerating Liver 3Prl-3 |
| Database Links | |
| Cellular Localisation | Cell MembraneEarly Endosome |
| Alternative Protein Names | Protein Tyrosine Phosphatase Type Iva 3 proteinPrl-R proteinProtein-Tyrosine Phosphatase 4a3 proteinProtein-Tyrosine Phosphatase Of Regenerating Liver 3 proteinPrl-3 proteinPTP4A3 proteinPRL3 protein |
Information sourced from Uniprot.org