Human PRKRA protein (Recombinant) (N-His) (STJP008154)

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STJP008154
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Host: E. coli
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Recombinant-Human PRKRA-N-His protein was developed from e. coli and has a target region of N-His. For use in research applications.
Formulation: Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Storage Instruction: Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt.
Gene Symbol: PRKRA
Gene ID: 8575
Uniprot ID: PRKRA_HUMAN
Immunogen Region: Asn126-Lys313
Immunogen: Homo sapiens (Human)
Function Activates EIF2AK2/PKR in the absence of double-stranded RNA (dsRNA), leading to phosphorylation of EIF2S1/EFI2-alpha and inhibition of translation and induction of apoptosis. Required for siRNA production by DICER1 and for subsequent siRNA-mediated post-transcriptional gene silencing. Does not seem to be required for processing of pre-miRNA to miRNA by DICER1. Promotes UBC9-p53/TP53 association and sumoylation and phosphorylation of p53/TP53 at 'Lys-386' at 'Ser-392' respectively and enhances its activity in a EIF2AK2/PKR-dependent manner.
Protein Name Interferon-Inducible Double-Stranded Rna-Dependent Protein Kinase Activator A
Pkr-Associated Protein X
Pkr-Associating Protein X
Protein Activator Of The Interferon-Induced Protein Kinase
Protein Kinase - Interferon-Inducible Double-Stranded Rna-Dependent Activator
Database Links Reactome: R-HSA-203927
Reactome: R-HSA-426486
Reactome: R-HSA-9833482
Cellular Localisation Cytoplasm
Perinuclear Region
Alternative Protein Names Interferon-Inducible Double-Stranded Rna-Dependent Protein Kinase Activator A protein
Pkr-Associated Protein X protein
Pkr-Associating Protein X protein
Protein Activator Of The Interferon-Induced Protein Kinase protein
Protein Kinase - Interferon-Inducible Double-Stranded Rna-Dependent Activator protein
PRKRA protein
PACT protein
RAX protein
HSD-14 protein
HSD14 protein

Information sourced from Uniprot.org

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