Human PRKG2 protein (Recombinant) (N-His) (STJP007959)
SPECIFICATIONS
HostE.coli
ImmunogenHomo sapiens (Human)
General Information
| Short Description | Recombinant-Human PRKG2-N-His protein was developed from e.coli for the region N-His. For use in research applications. |
| Applications | ELISA/Immunogen/SDS-PAGE/WB |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Dilution Range | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| Formulation | Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol. |
| Storage Instruction | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt. |
Target Information
| Gene Symbol | PRKG2 |
| Gene ID | 5593 |
| Uniprot ID | KGP2_HUMAN |
| Immunogen | Homo sapiens (Human) |
| Immunogen Region | Ser431-Phe762 |
Additional Info
| Post Translational Modifications | Myristoylation mediates membrane localization. |
| Function | Crucial regulator of intestinal secretion and bone growth. Phosphorylates and activates CFTR on the plasma membrane. Plays a key role in intestinal secretion by regulating cGMP-dependent translocation of CFTR in jejunum. Acts downstream of NMDAR to activate the plasma membrane accumulation of GRIA1/GLUR1 in synapse and increase synaptic plasticity. Phosphorylates GRIA1/GLUR1 at Ser-863. Acts as a regulator of gene expression and activator of the extracellular signal-regulated kinases MAPK3/ERK1 and MAPK1/ERK2 in mechanically stimulated osteoblasts. Under fluid shear stress, mediates ERK activation and subsequent induction of FOS, FOSL1/FRA1, FOSL2/FRA2 and FOSB that play a key role in the osteoblast anabolic response to mechanical stimulation. |
| Protein Name | Cgmp-Dependent Protein Kinase 2Cgk 2Cgk2Cgmp-Dependent Protein Kinase IiCgkii |
| Database Links | Reactome: R-HSA-1474151Reactome: R-HSA-4086398Reactome: R-HSA-418457Reactome: R-HSA-9648002 |
| Cellular Localisation | Apical Cell MembraneLipid-Anchor |
| Alternative Protein Names | Cgmp-Dependent Protein Kinase 2 proteinCgk 2 proteinCgk2 proteinCgmp-Dependent Protein Kinase Ii proteinCgkii proteinPRKG2 proteinPRKGR2 protein |
Information sourced from Uniprot.org