Human PRICKLE1 protein (Recombinant) (N-His) (STJP008163)

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STJP008163
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Host: E. coli
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Recombinant-Human PRICKLE1-N-His protein was developed from e. coli and has a target region of N-His. For use in research applications.
Formulation: Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Storage Instruction: Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt.
Gene Symbol: PRICKLE1
Gene ID: 144165
Uniprot ID: PRIC1_HUMAN
Immunogen Region: Arg41-Ser327
Immunogen: Homo sapiens (Human)
Function Involved in the planar cell polarity pathway that controls convergent extension during gastrulation and neural tube closure. Convergent extension is a complex morphogenetic process during which cells elongate, move mediolaterally, and intercalate between neighboring cells, leading to convergence toward the mediolateral axis and extension along the anteroposterior axis. Necessary for nuclear localization of REST. May serve as nuclear receptor.
Protein Name Prickle-Like Protein 1
Rest/Nrsf-Interacting Lim Domain Protein 1
Database Links Reactome: R-HSA-4608870
Cellular Localisation Nucleus Membrane
Cytoplasm
Cytosol
A Smaller Amount Is Detected In The Cytosol
Alternative Protein Names Prickle-Like Protein 1 protein
Rest/Nrsf-Interacting Lim Domain Protein 1 protein
PRICKLE1 protein
RILP protein

Information sourced from Uniprot.org