Function | Involved in the planar cell polarity pathway that controls convergent extension during gastrulation and neural tube closure. Convergent extension is a complex morphogenetic process during which cells elongate, move mediolaterally, and intercalate between neighboring cells, leading to convergence toward the mediolateral axis and extension along the anteroposterior axis. Necessary for nuclear localization of REST. May serve as nuclear receptor. |
Protein Name | Prickle-Like Protein 1Rest/Nrsf-Interacting Lim Domain Protein 1 |
Database Links | Reactome: R-HSA-4608870 |
Cellular Localisation | Nucleus MembraneCytoplasmCytosolA Smaller Amount Is Detected In The Cytosol |
Alternative Protein Names | Prickle-Like Protein 1 proteinRest/Nrsf-Interacting Lim Domain Protein 1 proteinPRICKLE1 proteinRILP protein |
Information sourced from Uniprot.org