Human PRG4 protein (Recombinant) (N-GST & C-His) (STJP015283)
SPECIFICATIONS
HostE.coli
ImmunogenHomo sapiens (Human)
General Information
| Short Description | Recombinant-Human PRG4-N-GST & C-His protein was developed from e.coli for the region N-GST & C-His. For use in research applications. |
| Applications | ELISA/Immunogen/SDS-PAGE/WB |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Dilution Range | Reconstitute in sterile water for a stock solution. |
| Formulation | Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. |
| Storage Instruction | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt. |
| Endotoxin | Please contact us for further information. |
Target Information
| Gene Symbol | PRG4 |
| Gene ID | 10216 |
| Uniprot ID | PRG4_HUMAN |
| Immunogen | Homo sapiens (Human) |
| Immunogen Region | Val1151-Gly1241 |
Additional Info
| Post Translational Modifications | N-glycosylated. O-glycosylated.contains glycosaminoglycan chondroitin sulfate and keratan sulfate. O-glycosylated with sialylated oligosaccharides which are predominantly represented by the monosialylated core type I structure, NeuNAcalpha2-3Galbeta1-3GalNAc, with smaller amounts of disialylated O-glycans. The disulfide bond between Cys-1146 and Cys-1403 is essential for protein cleavage. Proteolytically cleaved by cathepsin CTSG. |
| Function | Plays a role in boundary lubrication within articulating joints. Prevents protein deposition onto cartilage from synovial fluid by controlling adhesion-dependent synovial growth and inhibiting the adhesion of synovial cells to the cartilage surface. Isoform F plays a role as a growth factor acting on the primitive cells of both hematopoietic and endothelial cell lineages. |
| Protein Name | Proteoglycan 4LubricinMegakaryocyte-Stimulating FactorSuperficial Zone Proteoglycan Cleaved Into - Proteoglycan 4 C-Terminal Part |
| Database Links | |
| Cellular Localisation | Secreted |
| Alternative Protein Names | Proteoglycan 4 proteinLubricin proteinMegakaryocyte-Stimulating Factor proteinSuperficial Zone Proteoglycan Cleaved Into - Proteoglycan 4 C-Terminal Part proteinPRG4 proteinMSF proteinSZP protein |
Information sourced from Uniprot.org