| Function | Guanine nucleotide exchange factor (GEF) that regulates the assembly of the coat protein complex II/COPII in endoplasmic reticulum (ER) to Golgi vesicle-mediated transport. Selectively activates SAR1A and SAR1B by promoting the exchange of guanosine diphosphate (GDP) for guanosine triphosphate (GTP) in these small GTPases. In their activated GTP-bound state, SAR1A and SAR1B insert into the membrane of the endoplasmic reticulum where they recruit the remainder of the coat protein complex II/COPII which is responsible for both the sorting of proteins and the deformation and budding of membranes into vesicles destined to the Golgi. Was first identified based on its probable role in the regulation of pituitary gene transcription. Binds to the prolactin gene (PRL) promoter and seems to activate transcription. |
| Protein Name | Guanine Nucleotide-Exchange Factor Sec12Prolactin Regulatory Element-Binding Protein |
| Database Links | Reactome: R-HSA-204005Reactome: R-HSA-381038Reactome: R-HSA-5694530 |
| Cellular Localisation | Endoplasmic Reticulum MembraneSingle-Pass Membrane ProteinNucleusConcentrates At Endoplasmic Reticulum Exit Sites (Eres)Also Known As Transitional Endoplasmic Reticulum (Ter) |
| Alternative Protein Names | Guanine Nucleotide-Exchange Factor Sec12 proteinProlactin Regulatory Element-Binding Protein proteinPREB proteinSEC12 protein |
Information sourced from Uniprot.org
