Human PRDX6 protein (Recombinant) (N-His) (STJP007436)

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STJP007436
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Host: E. coli
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Recombinant-Human PRDX6-N-His protein was developed from e. coli and has a target region of N-His. For use in research applications.
Formulation: Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Storage Instruction: Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt.
Gene Symbol: PRDX6
Gene ID: 9588
Uniprot ID: PRDX6_HUMAN
Immunogen Region: Met1-Pro224
Immunogen: Homo sapiens (Human)
Function Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Can reduce H(2)O(2) and short chain organic, fatty acid, and phospholipid hydroperoxides. Also has phospholipase activity, can therefore either reduce the oxidized sn-2 fatty acyl group of phospholipids (peroxidase activity) or hydrolyze the sn-2 ester bond of phospholipids (phospholipase activity). These activities are dependent on binding to phospholipids at acidic pH and to oxidized phospholipds at cytosolic pH. Plays a role in cell protection against oxidative stress by detoxifying peroxides and in phospholipid homeostasis. Exhibits acyl-CoA-dependent lysophospholipid acyltransferase which mediates the conversion of lysophosphatidylcholine (1-acyl-sn-glycero-3-phosphocholine or LPC) into phosphatidylcholine (1,2-diacyl-sn-glycero-3-phosphocholine or PC). Shows a clear preference for LPC as the lysophospholipid and for palmitoyl CoA as the fatty acyl substrate.
Protein Name Peroxiredoxin-6
1-Cys Peroxiredoxin
1-Cys Prx
24 Kda Protein
Acidic Calcium-Independent Phospholipase A2
Aipla2
Antioxidant Protein 2
Glutathione-Dependent Peroxiredoxin
Liver 2d Page Spot 40
Lysophosphatidylcholine Acyltransferase 5
Lpc Acyltransferase 5
Lpcat-5
Lyso-Pc Acyltransferase 5
Non-Selenium Glutathione Peroxidase
Nsgpx
Red Blood Cells Page Spot 12
Database Links Reactome: R-HSA-3299685
Reactome: R-HSA-6798695
Cellular Localisation Cytoplasm
Lysosome
Also Found In Lung Secretory Organelles (Lamellar Bodies)
Alternative Protein Names Peroxiredoxin-6 protein
1-Cys Peroxiredoxin protein
1-Cys Prx protein
24 Kda Protein protein
Acidic Calcium-Independent Phospholipase A2 protein
Aipla2 protein
Antioxidant Protein 2 protein
Glutathione-Dependent Peroxiredoxin protein
Liver 2d Page Spot 40 protein
Lysophosphatidylcholine Acyltransferase 5 protein
Lpc Acyltransferase 5 protein
Lpcat-5 protein
Lyso-Pc Acyltransferase 5 protein
Non-Selenium Glutathione Peroxidase protein
Nsgpx protein
Red Blood Cells Page Spot 12 protein
PRDX6 protein
AOP2 protein
KIAA0106 protein

Information sourced from Uniprot.org

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