| Tissue Specificity | Widely expressed. |
| Post Translational Modifications | S-palmitoylated. Palmitoylation occurs on the active site, inhibiting its reactivity.therefore PRDX5 palmitoylation status determines its antioxidant capacity. Isoform Mitochondrial: S-palmitoylated. Depalmitoylated by ABHD10. |
| Function | Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides and as sensor of hydrogen peroxide-mediated signaling events. |
| Protein Name | Peroxiredoxin-5 - MitochondrialAlu Corepressor 1Antioxidant Enzyme B166Aoeb166Liver Tissue 2d-Page Spot 71bPlpPeroxiredoxin VPrx-VPeroxisomal Antioxidant EnzymeTpx Type ViThioredoxin Peroxidase Pmp20Thioredoxin-Dependent Peroxiredoxin 5 |
| Database Links | Reactome: R-HSA-3299685Reactome: R-HSA-5628897 P30044-2 |
| Cellular Localisation | Isoform Mitochondrial: MitochondrionIsoform Cytoplasmic+Peroxisomal: CytoplasmPeroxisome MatrixImported Into Peroxisomes Via Peroxisomal Targeting Signal 1 Receptor Pex5 |
| Alternative ELISA Names | Peroxiredoxin-5 - Mitochondrial ELISA kitAlu Corepressor 1 ELISA kitAntioxidant Enzyme B166 ELISA kitAoeb166 ELISA kitLiver Tissue 2d-Page Spot 71b ELISA kitPlp ELISA kitPeroxiredoxin V ELISA kitPrx-V ELISA kitPeroxisomal Antioxidant Enzyme ELISA kitTpx Type Vi ELISA kitThioredoxin Peroxidase Pmp20 ELISA kitThioredoxin-Dependent Peroxiredoxin 5 ELISA kitPRDX5 ELISA kitACR1 ELISA kitSBBI10 ELISA kit |
| output | |
Information sourced from Uniprot.org
