| Tissue Specificity | |
| Post Translational Modifications | The enzyme can be inactivated by further oxidation of the cysteine sulfenic acid (C(P)-SOH) to sulphinic acid (C(P)-SO2H) instead of its condensation to a disulfide bond. It can be reactivated by forming a transient disulfide bond with sulfiredoxin SRXN1, which reduces the cysteine sulfinic acid in an ATP- and Mg-dependent manner. |
| Function | Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides and as sensor of hydrogen peroxide-mediated signaling events. Might participate in the signaling cascades of growth factors and tumor necrosis factor-alpha by regulating the intracellular concentrations of H(2)O(2). |
| Protein Name | Peroxiredoxin-2Natural Killer Cell-Enhancing Factor BNkef-BPrpThiol-Specific Antioxidant ProteinTsaThioredoxin Peroxidase 1Thioredoxin-Dependent Peroxide Reductase 1Thioredoxin-Dependent Peroxiredoxin 2 |
| Database Links | Reactome: R-HSA-3299685Reactome: R-HSA-5628897Reactome: R-HSA-8862803 |
| Cellular Localisation | Cytoplasm |
| Alternative ELISA Names | Peroxiredoxin-2 ELISA kitNatural Killer Cell-Enhancing Factor B ELISA kitNkef-B ELISA kitPrp ELISA kitThiol-Specific Antioxidant Protein ELISA kitTsa ELISA kitThioredoxin Peroxidase 1 ELISA kitThioredoxin-Dependent Peroxide Reductase 1 ELISA kitThioredoxin-Dependent Peroxiredoxin 2 ELISA kitPRDX2 ELISA kitNKEFB ELISA kitTDPX1 ELISA kit |
| output | |
Information sourced from Uniprot.org
