| Function | Transcription factor that mediates a transcriptional program in various innate and adaptive immune tissue-resident lymphocyte T cell types such as tissue-resident memory T (Trm), natural killer (trNK) and natural killer T (NKT) cells and negatively regulates gene expression of proteins that promote the egress of tissue-resident T-cell populations from non-lymphoid organs. Plays a role in the development, retention and long-term establishment of adaptive and innate tissue-resident lymphocyte T cell types in non-lymphoid organs, such as the skin and gut, but also in other nonbarrier tissues like liver and kidney, and therefore may provide immediate immunological protection against reactivating infections or viral reinfection. Binds specifically to the PRDI element in the promoter of the beta-interferon gene. Drives the maturation of B-lymphocytes into Ig secreting cells. Associates with the transcriptional repressor ZNF683 to chromatin at gene promoter regions. Binds to the promoter and acts as a transcriptional repressor of IRF8, thereby promotes transcription of osteoclast differentiation factors such as NFATC1 and EEIG1. |
| Protein Name | Pr Domain Zinc Finger Protein 1Blimp-1Beta-Interferon Gene Positive Regulatory Domain I-Binding FactorPr Domain-Containing Protein 1Positive Regulatory Domain I-Binding Factor 1Prdi-Bf1Prdi-Binding Factor 1 |
| Database Links | Reactome: R-HSA-6804754Reactome: R-HSA-9701898Reactome: R-HSA-9827857 |
| Cellular Localisation | NucleusCytoplasm |
| Alternative Protein Names | Pr Domain Zinc Finger Protein 1 proteinBlimp-1 proteinBeta-Interferon Gene Positive Regulatory Domain I-Binding Factor proteinPr Domain-Containing Protein 1 proteinPositive Regulatory Domain I-Binding Factor 1 proteinPrdi-Bf1 proteinPrdi-Binding Factor 1 proteinPRDM1 proteinBLIMP1 protein |
Information sourced from Uniprot.org
