Human PRDC/GREM2 protein (Recombinant) (His-Tag) (STJP018156)
SPECIFICATIONS
HostE.coli
ImmunogenHuman
General Information
| Short Description | Recombinant-Human PRDC/GREM2-His-Tag protein was developed from e.coli and has a target region of His-Tag. For use in research applications. |
| Applications | SDS-PAGE/Denatured |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Concentration | 1 mg/mL |
| Formulation | Liquid in 20mM Tris-HCl buffer (pH 8.0) containing 0.4M urea, 10% Glycerol |
| Storage Instruction | For short term storage, keep at +2C to +8C for up to 1 week. For long term storage, aliquot and store at-20C, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | GREM2 |
| Gene ID | 64388 |
| Uniprot ID | GREM2_HUMAN |
| Accession Number | NP_071914 |
| Immunogen | Human |
| Immunogen Region | 22-168aa |
| Immunogen Sequence | MGSSHHHHHH SSGLVPRGSH MGSRKNRPAG AIPSPYKDGS SNNSERWQHQ IKEVLASSQE ALVVTERKYL KSDWCKTQPL RQTVSEEGCR SRTILNRFCY GQCNSFYIPR HVKKEEESFQ SCAFCKPQRV TSVLVELECP GLDPPFRLKK IQKVKQCRCM SVNLSDSDKQ |
Additional Info
| Post Translational Modifications | N-glycosylated. |
| Function | Cytokine that inhibits the activity of BMP2 and BMP4 in a dose-dependent manner, and thereby modulates signaling by BMP family members. Contributes to the regulation of embryonic morphogenesis via BMP family members. Antagonizes BMP4-induced suppression of progesterone production in granulosa cells. |
| Protein Name | Gremlin-2Cysteine Knot Superfamily 1 - Bmp Antagonist 2Dan Domain Family Member 3Protein Related To Dan And Cerberus |
| Database Links | Reactome: R-HSA-201451 |
| Cellular Localisation | Secreted |
| Alternative Protein Names | Gremlin-2 proteinCysteine Knot Superfamily 1 - Bmp Antagonist 2 proteinDan Domain Family Member 3 proteinProtein Related To Dan And Cerberus proteinGREM2 proteinCKTSF1B2 proteinDAND3 proteinPRDC protein |
Information sourced from Uniprot.org