| Host: | HEK293 Cells |
| Applications: | SDS-PAGE/Enzyme Activity |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Recombinant-Human PRCP-His-Tag protein was developed from hek293 cells and has a target region of His-Tag. For use in research applications. |
| Formulation: | Liquid In Phosphate-Buffered Saline (pH 7.4) containing 30% Glycerol |
| Concentration: | 0.25 mg/mL |
| Storage Instruction: | For short term storage, keep at +2C to +8C for up to 1 week. For long term storage, aliquot and store at-20C, and avoid repeat freeze-thaw cycles. |
| Endotoxin: | < 1 EU per 1ug of protein (determined by LAL method) |
| Immunoreactivity: | Specific activity is > 3, 000 pmol/min/Mu g, and is defined as the amount of enzyme that convert 1.0 pmole of Z-Pro-Ala-OH per minute at pH 4.0 at 25C. |
| Gene Symbol: | PRCP |
| Gene ID: | 5547 |
| Uniprot ID: | PCP_HUMAN |
| Immunogen Region: | 22-496aa |
| Accession Number: | NP_005031.1 |
| Immunogen: | Human |
| Immunogen Sequence: | LRPALRALGS LHLPTNPTSL PAVAKNYSVL YFQQKVDHFG FNTVKTFNQR YLVADKYWKK NGGSILFYTG NEGDIIWFCN NTGFMWDVAE ELKAMLVFAE HRYYGESLPF GDNSFKDSRH LNFLTSEQAL ADFAELIKHL KRTIPGAENQ PVIAIGGSYG GMLAAWFRMK YPHMVVGALA ASAPIWQFED LVPCGVFMKI VTTDFRKSGP HCSESIHRSW DAINRLSN |
| Tissue Specificity | Highest levels in placenta, lung and liver. Also present in heart, brain, pancreas and kidney. |
| Function | Cleaves C-terminal amino acids linked to proline in peptides such as angiotensin II, III and des-Arg9-bradykinin. This cleavage occurs at acidic pH, but enzymatic activity is retained with some substrates at neutral pH. |
| Protein Name | Lysosomal Pro-X CarboxypeptidaseAngiotensinase CLysosomal Carboxypeptidase CProline CarboxypeptidaseProlylcarboxypeptidasePrcp |
| Database Links | Reactome: R-HSA-140837Reactome: R-HSA-6798695 |
| Cellular Localisation | Lysosome |
| Alternative Protein Names | Lysosomal Pro-X Carboxypeptidase proteinAngiotensinase C proteinLysosomal Carboxypeptidase C proteinProline Carboxypeptidase proteinProlylcarboxypeptidase proteinPrcp proteinPRCP proteinPCP protein |
Information sourced from Uniprot.org