Human PPP6C protein (Recombinant) (N-His) (STJP010613)

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STJP010613
£328.50 - £1,437.50
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Host: E. coli
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Recombinant-Human PPP6C-N-His protein was developed from e. coli and has a target region of N-His. For use in research applications.
Formulation: Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Storage Instruction: Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt.
Gene Symbol: PPP6C
Gene ID: 5537
Uniprot ID: PPP6_HUMAN
Immunogen Region: Met1-Leu305
Immunogen: Homo sapiens (Human)
Function Catalytic subunit of protein phosphatase 6 (PP6). PP6 is a component of a signaling pathway regulating cell cycle progression in response to IL2 receptor stimulation. N-terminal domain restricts G1 to S phase progression in cancer cells, in part through control of cyclin D1. During mitosis, regulates spindle positioning. Down-regulates MAP3K7 kinase activation of the IL1 signaling pathway by dephosphorylation of MAP3K7. Participates also in the innate immune defense against viruses by desphosphorylating RIGI, an essential step that triggers RIGI-mediated signaling activation. Also regulates innate immunity by acting as a negative regulator of the cGAS-STING pathway: mediates dephosphorylation and inactivation of CGAS and STING1. CGAS dephosphorylation at 'Ser-435' impairs its ability to bind GTP, thereby inactivating it.
Protein Name Serine/Threonine-Protein Phosphatase 6 Catalytic Subunit
Pp6c Cleaved Into - Serine/Threonine-Protein Phosphatase 6 Catalytic Subunit - N-Terminally Processed
Database Links Reactome: R-HSA-171319
Reactome: R-HSA-204005
Cellular Localisation Mitochondrion
Cytoplasm
Alternative Protein Names Serine/Threonine-Protein Phosphatase 6 Catalytic Subunit protein
Pp6c Cleaved Into - Serine/Threonine-Protein Phosphatase 6 Catalytic Subunit - N-Terminally Processed protein
PPP6C protein
PPP6 protein

Information sourced from Uniprot.org

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