Human PPIE protein (Recombinant) (N-His) (STJP014706)

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STJP014706-100
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Short Description :Recombinant-Human PPIE-N-His protein was developed from e.coli and has a target region of N-His. For use in research applications.
Applications:ELISA/WB
Host:E.coli
Note:STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Conjugation:Unconjugated
Formulation:Supplied as a 0.22 Mu m filtered solution in 20mM Tris-HCl, pH 8.0.
Storage Instruction:Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for one week. Store at-20 to-80°C for twelve months from the date of receipt.
Endotoxin:< 1 EU/µg as determined by LAL test.
Gene Symbol:PPIE
Gene ID:10450
Uniprot ID:PPIE_HUMAN
Immunogen:Homo sapiens (Human)
Immunogen Region:Met1-Val301
Function Involved in pre-mRNA splicing as component of the spliceosome. Combines RNA-binding and PPIase activities. Binds mRNA and has a preference for single-stranded RNA molecules with poly-A and poly-U stretches, suggesting it binds to the poly(A)-region in the 3'-UTR of mRNA molecules. Catalyzes the cis-trans isomerization of proline imidic peptide bonds in proteins. Inhibits KMT2A activity.this requires proline isomerase activity.
Protein Name Peptidyl-Prolyl Cis-Trans Isomerase E
Ppiase E
Cyclophilin E
Cyclophilin-33
Rotamase E
Database Links Reactome: R-HSA-6781823
Reactome: R-HSA-6781827
Reactome: R-HSA-6782135
Reactome: R-HSA-6782210
Reactome: R-HSA-6798695
Reactome: R-HSA-72163
Cellular Localisation Nucleus
Alternative Protein Names Peptidyl-Prolyl Cis-Trans Isomerase E protein
Ppiase E protein
Cyclophilin E protein
Cyclophilin-33 protein
Rotamase E protein
PPIE protein
CYP33 protein

Information sourced from Uniprot.org