Human PPARD protein (Recombinant) (N-His) (STJP005168)

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STJP005168
£328.50 - £1,437.50
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Host: E. coli
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Recombinant-Human PPARD-N-His protein was developed from e. coli and has a target region of N-His. For use in research applications.
Formulation: Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Storage Instruction: Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt.
Gene Symbol: PPARD
Gene ID: 5467
Uniprot ID: PPARD_HUMAN
Immunogen Region: Leu260-Glu426
Immunogen: Homo sapiens (Human)
Post Translational Modifications 'Lys-48'-linked polyubiquitinated.leading to proteasomal degradation. Deubiquitinated and stabilized by OTUD3.
Function Ligand-activated transcription factor key mediator of energy metabolism in adipose tissues. Receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Has a preference for poly-unsaturated fatty acids, such as gamma-linoleic acid and eicosapentanoic acid. Once activated by a ligand, the receptor binds to promoter elements of target genes. Regulates the peroxisomal beta-oxidation pathway of fatty acids. Functions as transcription activator for the acyl-CoA oxidase gene. Decreases expression of NPC1L1 once activated by a ligand.
Protein Name Peroxisome Proliferator-Activated Receptor Delta
Ppar-Delta
Nuci
Nuclear Hormone Receptor 1
Nuc1
Nuclear Receptor Subfamily 1 Group C Member 2
Peroxisome Proliferator-Activated Receptor Beta
Ppar-Beta
Database Links Reactome: R-HSA-200425
Reactome: R-HSA-383280
Reactome: R-HSA-5362517
Cellular Localisation Nucleus
Alternative Protein Names Peroxisome Proliferator-Activated Receptor Delta protein
Ppar-Delta protein
Nuci protein
Nuclear Hormone Receptor 1 protein
Nuc1 protein
Nuclear Receptor Subfamily 1 Group C Member 2 protein
Peroxisome Proliferator-Activated Receptor Beta protein
Ppar-Beta protein
PPARD protein
NR1C2 protein
PPARB protein

Information sourced from Uniprot.org

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