Human PP2C alpha/PPM1A protein (Recombinant) (His-Tag) (STJP019729)

SKU:
STJP019729
£110.50 - £535.50
Processing The item has been added
Enquire For Bulk Order

Covered by St John's Laboratory Guarantee

Host: E.coli
Applications: SDS-PAGE/Enzyme Activity
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Recombinant-Human PP2C alpha/PPM1A-His-Tag protein was developed from e.coli and has a target region of His-Tag. For use in research applications.
Formulation: Liquid in 10mM Tris-HCl buffer (pH 7.5) containing 50mM NaCl, 2mM DTT, 1mM MnCl2, 20%Glycerol
Concentration: 1 mg/mL
Storage Instruction: For short term storage, keep at +2C to +8C for up to 1 week. For long term storage, aliquot and store at-20C, and avoid repeat freeze-thaw cycles.
Endotoxin: < 1 EU per 1ug of protein (determined by LAL method)
Immunoreactivity: Specific activity is > 1, 400unit/mg, and is defined as the amount of enzyme that hydrolyze 1.0nmole of p-nitrophenyl phosphate (pNPP) per minute at pH 7.5 at 37C.
Gene Symbol: PPM1A
Gene ID: 5494
Uniprot ID: PPM1A_HUMAN
Immunogen Region: 1-382aa
Accession Number: NP_066283
Immunogen: Human
Immunogen Sequence: MGAF LDKPKMEKHN AQGQGNGLRY GLSSMQGWRV EMEDAHTAVI GLPSGLESWS FFAVYDGHAG SQVAKYCCEH LLDHITNNQD FKGSAGAPSV ENVKNGIRTG FLEIDEHMRV MSEKKHGADR SGSTAVGVLI SPQHTYFINC GDSRGLLCRN RKVHFFTQDH KPSNPLEKER IQNAGGSVMI QRVNGS
Post Translational Modifications N-myristoylation is essential for the recognition of its substrates for dephosphorylation.
Function Enzyme with a broad specificity. Negatively regulates TGF-beta signaling through dephosphorylating SMAD2 and SMAD3, resulting in their dissociation from SMAD4, nuclear export of the SMADs and termination of the TGF-beta-mediated signaling. Dephosphorylates PRKAA1 and PRKAA2. Plays an important role in the termination of TNF-alpha-mediated NF-kappa-B activation through dephosphorylating and inactivating IKBKB/IKKB.
Protein Name Protein Phosphatase 1a
Protein Phosphatase 2c Isoform Alpha
Pp2c-Alpha
Protein Phosphatase Ia
Database Links Reactome: R-HSA-2173795
Reactome: R-HSA-380972
Cellular Localisation Nucleus
Cytoplasm
Cytosol
Membrane
Lipid-Anchor
Weakly Associates At The Membrane And N-Myristoylation Mediates The Membrane Localization
Alternative Protein Names Protein Phosphatase 1a protein
Protein Phosphatase 2c Isoform Alpha protein
Pp2c-Alpha protein
Protein Phosphatase Ia protein
PPM1A protein
PPPM1A protein

Information sourced from Uniprot.org

Related Products

Model Name Host Clonality Reactivity Application
STJP019732 Human PP2C gamma/PPM1G protein (Recombinant) (His-Tag) (STJP019732) E.coli SDS-PAGE
STJP019382 Human PP2C gamma/PPM1G protein (Recombinant) (His-Tag) (STJP019382) E.coli SDS-PAGE
STJP014489 Human PPM1A protein (Recombinant) (C-His) (STJP014489) E.coli ELISA/WB
STJP004631 Human PPM1A protein (Recombinant) (N-His) (STJP004631) E.coli ELISA/Immunogen/SDS-PAGE/WB
STJP019097 Human CNTFR alpha protein (Recombinant) (His-Tag) (STJP019097) E.coli SDS-PAGE/Denatured

Related Products

!