| Applications: | ELISA |
| Reactivity: | Human |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Sensitivity: | 30.9pg/mL |
| Detection Limit: | 78.1-5000pg/mL |
| Short Description: | This PP2Aa Sandwich ELISA Kit, Ready-To-Use is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in human serum, plasma, tissue homogenates or other biological fluids.. |
| Storage Instruction: | The whole kit may be stored at-20°C for up to 12 months from receipt. An unopened kit may be stored in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit. |
| Assay Time: | 3 hrs |
| Gene Symbol: | PPP2R1A |
| Gene ID: | 5518 |
| Uniprot ID: | 2AAA_HUMAN |
| Immunogen Region: | Ready-To-Use |
| Sample Type: | serum, plasma, tissue homogenates or other biological fluids. |
| Tissue Specificity | |
| Post Translational Modifications | |
| Function | The PR65 subunit of protein phosphatase 2A serves as a scaffolding molecule to coordinate the assembly of the catalytic subunit and a variable regulatory B subunit. Upon interaction with GNA12 promotes dephosphorylation of microtubule associated protein TAU/MAPT. Required for proper chromosome segregation and for centromeric localization of SGO1 in mitosis. Together with RACK1 adapter, mediates dephosphorylation of AKT1 at 'Ser-473', preventing AKT1 activation and AKT-mTOR signaling pathway. Dephosphorylation of AKT1 is essential for regulatory T-cells (Treg) homeostasis and stability. Part of the striatin-interacting phosphatase and kinase (STRIPAK) complexes. STRIPAK complexes have critical roles in protein (de)phosphorylation and are regulators of multiple signaling pathways including Hippo, MAPK, nuclear receptor and cytoskeleton remodeling. Different types of STRIPAK complexes are involved in a variety of biological processes such as cell growth, differentiation, apoptosis, metabolism and immune regulation. Regulates the recruitment of the SKA complex to kinetochores. |
| Protein Name | Serine/Threonine-Protein Phosphatase 2a 65 Kda Regulatory Subunit A Alpha IsoformMedium Tumor Antigen-Associated 61 Kda ProteinPp2a Subunit A Isoform Pr65-AlphaPp2a Subunit A Isoform R1-Alpha |
| Database Links | Reactome: R-HSA-113501Reactome: R-HSA-1295596Reactome: R-HSA-141444Reactome: R-HSA-163685Reactome: R-HSA-163767Reactome: R-HSA-180024Reactome: R-HSA-195253Reactome: R-HSA-196299Reactome: R-HSA-198753Reactome: R-HSA-202670Reactome: R-HSA-2465910Reactome: R-HSA-2467813Reactome: R-HSA-2500257Reactome: R-HSA-2565942Reactome: R-HSA-2995383Reactome: R-HSA-380259Reactome: R-HSA-380270Reactome: R-HSA-380284Reactome: R-HSA-380320Reactome: R-HSA-389513Reactome: R-HSA-432142Reactome: R-HSA-4641262Reactome: R-HSA-5339716Reactome: R-HSA-5358747Reactome: R-HSA-5358749Reactome: R-HSA-5358751Reactome: R-HSA-5358752Reactome: R-HSA-5467337Reactome: R-HSA-5467340Reactome: R-HSA-5467348Reactome: R-HSA-5620912Reactome: R-HSA-5663220Reactome: R-HSA-5673000Reactome: R-HSA-5675221Reactome: R-HSA-6804757Reactome: R-HSA-6811558Reactome: R-HSA-68877Reactome: R-HSA-69231Reactome: R-HSA-69273Reactome: R-HSA-8854518Reactome: R-HSA-9634600Reactome: R-HSA-9648025Reactome: R-HSA-975957Reactome: R-HSA-9833482 |
| Cellular Localisation | CytoplasmNucleusChromosomeCentromereLateral Cell MembraneCell ProjectionDendriteCentromeric Localization Requires The Presence Of Bub1 |
| Alternative ELISA Names | Serine/Threonine-Protein Phosphatase 2a 65 Kda Regulatory Subunit A Alpha Isoform ELISA kitMedium Tumor Antigen-Associated 61 Kda Protein ELISA kitPp2a Subunit A Isoform Pr65-Alpha ELISA kitPp2a Subunit A Isoform R1-Alpha ELISA kitPPP2R1A ELISA kit |
| output |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
