Human PP1 subunit R4/PPP1R3B protein (Recombinant) (His-Tag) (STJP018433)
SPECIFICATIONS
HostE.coli
ImmunogenHuman
General Information
| Short Description | Recombinant-Human PP1 subunit R4/PPP1R3B-His-Tag protein was developed from e.coli and has a target region of His-Tag. For use in research applications. |
| Applications | SDS-PAGE/Denatured |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Concentration | 1 mg/mL |
| Formulation | Liquid in 20mM Tris-HCl buffer (pH 8.0) containing 0.4M urea, 10% Glycerol |
| Storage Instruction | For short term storage, keep at +2C to +8C for up to 1 week. For long term storage, aliquot and store at-20C, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | PPP1R3B |
| Gene ID | 79660 |
| Uniprot ID | PPR3B_HUMAN |
| Accession Number | NP_001188258 |
| Immunogen | Human |
| Immunogen Region | 1-285aa |
| Immunogen Sequence | MGSSHHHHHH SSGLVPRGSH MGSMMAVDIE YRYNCMAPSL RQERFAFKIS PKPSKPLRPC IQLSSKNEAS GMVAPAVQEK KVKKRVSFAD NQGLALTMVK VFSEFDDPLD MPFNITELLD NIVSLTTAES ESFVLDFSQP SADYLDFRNR LQADHVCLEN CVLKDKAIAG TVKVQNLAFE KTVKIRMTFD TWKSYTDFPC QYVKDTYAGS DRDTFSFDIS LPEKIQSY |
Additional Info
| Tissue Specificity | Highly expressed in the liver and, at lower levels, in skeletal muscle, including in vastus lateralis, gastrocnemius and soleus (at protein level). Highest mRNA levels are observed in skeletal muscle, and only moderate levels in liver and heart. Weak expression in placenta and lung. |
| Function | Acts as a glycogen-targeting subunit for phosphatase PP1. Facilitates interaction of the PP1 with enzymes of the glycogen metabolism and regulates its activity. Suppresses the rate at which PP1 dephosphorylates (inactivates) glycogen phosphorylase and enhances the rate at which it activates glycogen synthase and therefore limits glycogen breakdown. Its activity is inhibited by PYGL, resulting in inhibition of the glycogen synthase and glycogen phosphorylase phosphatase activities of PP1. Dramatically increases basal and insulin-stimulated glycogen synthesis upon overexpression in hepatocytes. |
| Protein Name | Protein Phosphatase 1 Regulatory Subunit 3bHepatic Glycogen-Targeting Protein Phosphatase 1 Regulatory Subunit GlProtein Phosphatase 1 Regulatory Subunit 4Pp1 Subunit R4Protein Phosphatase 1 Subunit GlPtg |
| Database Links | |
| Cellular Localisation | |
| Alternative Protein Names | Protein Phosphatase 1 Regulatory Subunit 3b proteinHepatic Glycogen-Targeting Protein Phosphatase 1 Regulatory Subunit Gl proteinProtein Phosphatase 1 Regulatory Subunit 4 proteinPp1 Subunit R4 proteinProtein Phosphatase 1 Subunit Gl proteinPtg proteinPPP1R3B proteinPPP1R4 protein |
Information sourced from Uniprot.org