Human POU2F1 protein (Recombinant) (N-His) (STJP004114)

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STJP004114
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Host: E. coli
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Recombinant-Human POU2F1-N-His protein was developed from e. coli and has a target region of N-His. For use in research applications.
Formulation: Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Storage Instruction: Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt.
Gene Symbol: POU2F1
Gene ID: 5451
Uniprot ID: PO2F1_HUMAN
Immunogen Region: Ala413-Val671
Immunogen: Homo sapiens (Human)
Post Translational Modifications Phosphorylated by PRKDC.
Function Transcription factor that binds to the octamer motif (5'-ATTTGCAT-3') and activates the promoters of the genes for some small nuclear RNAs (snRNA) and of genes such as those for histone H2B and immunoglobulins. Modulates transcription transactivation by NR3C1, AR and PGR. (Microbial infection) In case of human herpes simplex virus (HSV) infection, POU2F1 forms a multiprotein-DNA complex with the viral transactivator protein VP16 and HCFC1 thereby enabling the transcription of the viral immediate early genes.
Protein Name Pou Domain - Class 2 - Transcription Factor 1
Nf-A1
Octamer-Binding Protein 1
Oct-1
Octamer-Binding Transcription Factor 1
Otf-1
Database Links Reactome: R-HSA-6785807
Reactome: R-HSA-6807505
Reactome: R-HSA-749476
Reactome: R-HSA-76071
Reactome: R-HSA-9018519
Cellular Localisation Nucleus
Alternative Protein Names Pou Domain - Class 2 - Transcription Factor 1 protein
Nf-A1 protein
Octamer-Binding Protein 1 protein
Oct-1 protein
Octamer-Binding Transcription Factor 1 protein
Otf-1 protein
POU2F1 protein
OCT1 protein
OTF1 protein

Information sourced from Uniprot.org

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