Human POMC protein (Recombinant) (N-His) (STJP003529)

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STJP003529
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Host: E. coli
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Recombinant-Human POMC-N-His protein was developed from e. coli and has a target region of N-His. For use in research applications.
Formulation: Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Storage Instruction: Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt.
Gene Symbol: POMC
Gene ID: 5443
Uniprot ID: COLI_HUMAN
Immunogen Region: Glu179-Glu267
Immunogen: Homo sapiens (Human)
Post Translational Modifications Specific enzymatic cleavages at paired basic residues yield the different active peptides. O-glycosylated.reducing sugar is probably N-acetylgalactosamine.
Function Corticotropin: Stimulates the adrenal glands to release cortisol. Melanocyte-stimulating hormone alpha: Anorexigenic peptide. Increases the pigmentation of skin by increasing melanin production in melanocytes. Melanocyte-stimulating hormone beta: Increases the pigmentation of skin by increasing melanin production in melanocytes. Beta-endorphin: Endogenous orexigenic opiate. Met-enkephalin: Endogenous opiate.
Protein Name Pro-Opiomelanocortin
Pomc
Corticotropin-Lipotropin Cleaved Into - Npp - Melanotropin Gamma
Gamma-Msh - Potential Peptide - Corticotropin
Adrenocorticotropic Hormone
Acth - Melanocyte-Stimulating Hormone Alpha
Alpha-Msh
Melanotropin Alpha - Corticotropin-Like Intermediary Peptide
Clip - Lipotropin Beta
Beta-Lph - Lipotropin Gamma
Gamma-Lph - Melanocyte-Stimulating Hormone Beta
Beta-Msh
Melanotropin Beta - Beta-Endorphin - Met-Enkephalin
Database Links Reactome: R-HSA-111885
Reactome: R-HSA-193048
Reactome: R-HSA-194002
Reactome: R-HSA-202040
Reactome: R-HSA-209952
Reactome: R-HSA-211976
Reactome: R-HSA-375276
Reactome: R-HSA-418555
Reactome: R-HSA-418594
Reactome: R-HSA-5579031
Reactome: R-HSA-6785807
Reactome: R-HSA-9615017
Reactome: R-HSA-9856649
Cellular Localisation Secreted
Melanocyte-Stimulating Hormone Alpha And Beta-Endorphin Are Stored In Separate Granules In Hypothalamic Pomc Neurons
Suggesting That Secretion May Be Under The Control Of Different Regulatory Mechanisms
Alternative Protein Names Pro-Opiomelanocortin protein
Pomc protein
Corticotropin-Lipotropin Cleaved Into - Npp - Melanotropin Gamma protein
Gamma-Msh - Potential Peptide - Corticotropin protein
Adrenocorticotropic Hormone protein
Acth - Melanocyte-Stimulating Hormone Alpha protein
Alpha-Msh protein
Melanotropin Alpha - Corticotropin-Like Intermediary Peptide protein
Clip - Lipotropin Beta protein
Beta-Lph - Lipotropin Gamma protein
Gamma-Lph - Melanocyte-Stimulating Hormone Beta protein
Beta-Msh protein
Melanotropin Beta - Beta-Endorphin - Met-Enkephalin protein
POMC protein

Information sourced from Uniprot.org

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