Human PLXNB1 protein (Recombinant) (N-His) (STJP011430)

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STJP011430
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Host: E. coli
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Recombinant-Human PLXNB1-N-His protein was developed from e. coli and has a target region of N-His. For use in research applications.
Formulation: Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Storage Instruction: Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for one week. Store at-20 to-80°C for twelve months from the date of receipt.
Gene Symbol: PLXNB1
Gene ID: 5364
Uniprot ID: PLXB1_HUMAN
Immunogen Region: Cys1067-Asp1251
Immunogen: Homo sapiens (Human)
Post Translational Modifications Phosphorylated on tyrosine residues by ERBB2 and MET upon SEMA4D binding. Proteolytic processing favors heterodimerization with PLXNB2 and SEMA4D binding.
Function Receptor for SEMA4D. Plays a role in GABAergic synapse development. Mediates SEMA4A- and SEMA4D-dependent inhibitory synapse development. Plays a role in RHOA activation and subsequent changes of the actin cytoskeleton. Plays a role in axon guidance, invasive growth and cell migration.
Protein Name Plexin-B1
Semaphorin Receptor Sep
Database Links Reactome: R-HSA-416482
Reactome: R-HSA-416550
Reactome: R-HSA-416572
Reactome: R-HSA-9013405
Cellular Localisation Isoform 1: Cell Membrane
Single-Pass Type I Membrane Protein
Isoform 2: Secreted
Isoform 3: Secreted
Alternative Protein Names Plexin-B1 protein
Semaphorin Receptor Sep protein
PLXNB1 protein
KIAA0407 protein
PLXN5 protein
SEP protein

Information sourced from Uniprot.org

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