Human PLEKHF2 protein (Recombinant) (His-Tag) (STJP018667)
SPECIFICATIONS
HostE.coli
ImmunogenHuman
General Information
| Short Description | Recombinant-Human PLEKHF2-His-Tag protein was developed from e.coli and has a target region of His-Tag. For use in research applications. |
| Applications | SDS-PAGE |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Concentration | 0.25 mg/mL |
| Formulation | Liquid in 20mM Tris-HCl buffer (pH 8.0) containing 0.15M NaCl, 10% Glycerol, 1mM DTT |
| Storage Instruction | For short term storage, keep at +2C to +8C for up to 1 week. For long term storage, aliquot and store at-20C, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | PLEKHF2 |
| Gene ID | 79666 |
| Uniprot ID | PKHF2_HUMAN |
| Accession Number | NP_078889 |
| Immunogen | Human |
| Immunogen Region | 1-249aa |
| Immunogen Sequence | MGSSHHHHHH SSGLVPRGSH MGSMVDRLAN SEANTRRISI VENCFGAAGQ PLTIPGRVLI GEGVLTKLCR KKPKARQFFL FNDILVYGNI VIQKKKYNKQ HIIPLENVTI DSIKDEGDLR NGWLIKTPTK SFAVYAATAT EKSEWMNHIN KCVTDLLSKS GKTPSNEHAA VWVPDSEATV CMRCQKAKFT PVNRRHHCRK CGFVVCGPCS EKRFLLPSQS SKPVRICD |
Additional Info
| Tissue Specificity | Expressed in placenta, ovary and small intestine, as well as in heart and pancreas. Also expressed in peripheral blood mononuclear cells and dendritic cells. |
| Function | May play a role in early endosome fusion upstream of RAB5, hence regulating receptor trafficking and fluid-phase transport. Enhances cellular sensitivity to TNF-induced apoptosis. |
| Protein Name | Pleckstrin Homology Domain-Containing Family F Member 2Ph Domain-Containing Family F Member 2Endoplasmic Reticulum-Associated Apoptosis-Involved Protein Containing Ph And Fyve DomainsEapfPh And Fyve Domain-Containing Protein 2Phafin-2Phafin2Zinc Finger Fyve Domain-Containing Protein 18 |
| Database Links | |
| Cellular Localisation | Early Endosome MembranePeripheral Membrane ProteinEndoplasmic ReticulumColocalizes With Eea1 And Rab5 At Endosomal Membrane Fusion Hot SpotsMay Translocate To The Endoplasmic Reticulum In The Early Phase Of Apoptosis |
| Alternative Protein Names | Pleckstrin Homology Domain-Containing Family F Member 2 proteinPh Domain-Containing Family F Member 2 proteinEndoplasmic Reticulum-Associated Apoptosis-Involved Protein Containing Ph And Fyve Domains proteinEapf proteinPh And Fyve Domain-Containing Protein 2 proteinPhafin-2 proteinPhafin2 proteinZinc Finger Fyve Domain-Containing Protein 18 proteinPLEKHF2 proteinZFYVE18 protein |
Information sourced from Uniprot.org