| Host: | E. coli |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Recombinant-Human PLCB1-N-His protein was developed from e. coli and has a target region of N-His. For use in research applications. |
| Formulation: | Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol. |
| Storage Instruction: | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt. |
| Gene Symbol: | PLCB1 |
| Gene ID: | 23236 |
| Uniprot ID: | PLCB1_HUMAN |
| Immunogen Region: | Lys27-Met245 |
| Immunogen: | Homo sapiens (Human) |
| Function | Catalyzes the hydrolysis of 1-phosphatidylinositol 4,5-bisphosphate into diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) and mediates intracellular signaling downstream of G protein-coupled receptors. Regulates the function of the endothelial barrier. |
| Protein Name | 1-Phosphatidylinositol 4 -5-Bisphosphate Phosphodiesterase Beta-1Plc-154Phosphoinositide Phospholipase C-Beta-1Phospholipase C-IPlc-IPhospholipase C-Beta-1Plc-Beta-1 |
| Database Links | Reactome: R-HSA-112043Reactome: R-HSA-1855204Reactome: R-HSA-399997Reactome: R-HSA-4086398Reactome: R-HSA-416476Reactome: R-HSA-418217Reactome: R-HSA-434316Reactome: R-HSA-500657 |
| Cellular Localisation | Nucleus MembraneCytoplasmColocalizes With The Adrenergic ReceptorsAdren1a And Adren1bAt The Nuclear Membrane Of Cardiac Myocytes |
| Alternative Protein Names | 1-Phosphatidylinositol 4 -5-Bisphosphate Phosphodiesterase Beta-1 proteinPlc-154 proteinPhosphoinositide Phospholipase C-Beta-1 proteinPhospholipase C-I proteinPlc-I proteinPhospholipase C-Beta-1 proteinPlc-Beta-1 proteinPLCB1 proteinKIAA0581 protein |
Information sourced from Uniprot.org