Human PLB1 protein (Recombinant) (N-His) (STJP005585)

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STJP005585
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Host: E. coli
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Recombinant-Human PLB1-N-His protein was developed from e. coli and has a target region of N-His. For use in research applications.
Formulation: Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Storage Instruction: Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt.
Gene Symbol: PLB1
Gene ID: 151056
Uniprot ID: PLB1_HUMAN
Immunogen Region: Met1036-Leu1458
Immunogen: Homo sapiens (Human)
Post Translational Modifications Undergoes proteolytic cleavage in the ileum.
Function Calcium-independent membrane-associated phospholipase that catalyzes complete diacylation of phospholipids by hydrolyzing both sn-1 and sn-2 fatty acyl chains attached to the glycerol backbone (phospholipase B activity). Has dual phospholipase and lysophospholipase activities toward diacylphospholipids. Preferentially cleaves sn-2 ester bonds over sn-1 bonds. Acts as a lipase toward glycerolipid substrates. Hydrolyzes fatty acyl chains of diacylglycerols with preference for the sn-2 position and of triacylglycerols with not positional selectivity. May also hydrolyze long chain retinyl esters such as retinyl palmitate. May contribute to digestion of dietary phospholipids, glycerolipids and retinoids, facilitating lipid absorption at the brush border.
Protein Name Phospholipase B1 - Membrane-Associated
Phospholipase B
Hplb
Lysophospholipase
Phospholipase A2
Phospholipase B/Lipase
Plb/Lip
Triacylglycerol Lipase
Database Links Reactome: R-HSA-1482788
Reactome: R-HSA-975634
Cellular Localisation Apical Cell Membrane
Single-Pass Type I Membrane Protein
Present In The Intestinal Brush Border Membranes
Alternative Protein Names Phospholipase B1 - Membrane-Associated protein
Phospholipase B protein
Hplb protein
Lysophospholipase protein
Phospholipase A2 protein
Phospholipase B/Lipase protein
Plb/Lip protein
Triacylglycerol Lipase protein
PLB1 protein
PLB protein

Information sourced from Uniprot.org

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