| Short Description : | Recombinant-Human Placenta growth factor/PLGF-131-C-hFc protein was developed in hek293 cells using the region Leu19-Arg149. For use in research applications. |
| Host: | HEK293 cells |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Conjugation: | Unconjugated |
| Formulation: | Lyophilised from a 0.22 Mu m filtered solution of PBS, pH 7.4. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Immunoreactivity: | Measured by its binding ability in a functional ELISA. Immobilized human VEGFR1/Flt-1 at 2 Mu g/mL (100 Mu L/well) can bind Human Placenta growth factor/PLGF-131 with a linear range of 0.17-41.1 ng/mL. |
| Determination Method: | < 0.1 EU/Mu g |
| Gene Symbol: | PGF |
| Gene ID: | 5228 |
| Uniprot ID: | PLGF_HUMAN |
| Immunogen: | Recombinant human PIG-F Protein is produced by HEK293 expression system. The target protein is expressed with sequence (Leu19-Arg149) fused with a hFc tag at the C-terminus. |
| Immunogen Region: | Leu19-Arg149 |
| Immunogen Sequence: | LPAVPPQQWALSAGNGSSEV EVVPFQEVWGRSYCRALERL VDVVSEYPSEVEHMFSPSCV SLLRCTGCCGDENLHCVPVE TANVTMQLLKIRSGDRPSYV ELTFSQHVRCECRPLREKMK PERCGDAVPRR |
| Post Translational Modifications | N-glycosylated. |
| Function | Growth factor active in angiogenesis and endothelial cell growth, stimulating their proliferation and migration. It binds to the receptor FLT1/VEGFR-1. Isoform PlGF-2 binds NRP1/neuropilin-1 and NRP2/neuropilin-2 in a heparin-dependent manner. Also promotes cell tumor growth. |
| Protein Name | Placenta Growth FactorPlgf |
| Database Links | Reactome: R-HSA-194313Reactome: R-HSA-195399 |
| Cellular Localisation | SecretedThe Three Isoforms Are Secreted But Plgf-2 Appears To Remain Cell Attached Unless Released By Heparin |
| Alternative Protein Names | Placenta Growth Factor proteinPlgf proteinPGF proteinPGFL proteinPLGF protein |
Information sourced from Uniprot.org
