| Post Translational Modifications | Activated by trypsin cleavage in the duodenum. Can also be activated by thrombin or autocatalytically. |
| Function | Secretory calcium-dependent phospholipase A2 that primarily targets dietary phospholipids in the intestinal tract. Hydrolyzes the ester bond of the fatty acyl group attached at sn-2 position of phospholipids (phospholipase A2 activity) with preference for phosphatidylethanolamines and phosphatidylglycerols over phosphatidylcholines. May play a role in the biosynthesis of N-acyl ethanolamines that regulate energy metabolism and inflammation in the intestinal tract. Hydrolyzes N-acyl phosphatidylethanolamines to N-acyl lysophosphatidylethanolamines, which are further cleaved by a lysophospholipase D to release N-acyl ethanolamines. May act in an autocrine and paracrine manner. Upon binding to the PLA2R1 receptor can regulate podocyte survival and glomerular homeostasis. Has anti-helminth activity in a process regulated by gut microbiota. Upon helminth infection of intestinal epithelia, directly affects phosphatidylethanolamine contents in the membrane of helminth larvae, likely controlling an array of phospholipid-mediated cellular processes such as membrane fusion and cell division while providing for better immune recognition, ultimately reducing larvae integrity and infectivity. |
| Protein Name | Phospholipase A2Group Ib Phospholipase A2Phosphatidylcholine 2-Acylhydrolase 1b |
| Database Links | Reactome: R-HSA-1482788Reactome: R-HSA-1482801Reactome: R-HSA-1482839Reactome: R-HSA-1482922Reactome: R-HSA-1482925Reactome: R-HSA-1483166 |
| Cellular Localisation | SecretedSecreted From Pancreatic Acinar Cells In Its Inactive Form |
| Alternative Protein Names | Phospholipase A2 proteinGroup Ib Phospholipase A2 proteinPhosphatidylcholine 2-Acylhydrolase 1b proteinPLA2G1B proteinPLA2 proteinPLA2A proteinPPLA2 protein |
Information sourced from Uniprot.org
