Human PITRM1 protein (Recombinant) (N-His) (STJP005551)
SPECIFICATIONS
HostE.coli
ImmunogenHomo sapiens (Human)
General Information
| Short Description | Recombinant-Human PITRM1-N-His protein was developed from e.coli for the region N-His. For use in research applications. |
| Applications | ELISA/Immunogen/SDS-PAGE/WB |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Dilution Range | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| Formulation | Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol. |
| Storage Instruction | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt. |
Target Information
| Gene Symbol | PITRM1 |
| Gene ID | 10531 |
| Uniprot ID | PREP_HUMAN |
| Immunogen | Homo sapiens (Human) |
| Immunogen Region | Leu544-Ser806 |
Additional Info
| Post Translational Modifications | A disulfide bond locks the enzyme in the closed conformation preventing substrate entry into the catalytic chamber. |
| Function | Metalloendopeptidase of the mitochondrial matrix that functions in peptide cleavage and degradation rather than in protein processing. Has an ATP-independent activity. Specifically cleaves peptides in the range of 5 to 65 residues. Shows a preference for cleavage after small polar residues and before basic residues, but without any positional preference. Degrades the transit peptides of mitochondrial proteins after their cleavage. Also degrades other unstructured peptides. It is also able to degrade amyloid-beta protein 40, one of the peptides produced by APP processing, when it accumulates in mitochondrion. It is a highly efficient protease, at least toward amyloid-beta protein 40. Cleaves that peptide at a specific position and is probably not processive, releasing digested peptides intermediates that can be further cleaved subsequently. It is also able to degrade amyloid-beta protein 42. |
| Protein Name | Presequence Protease - MitochondrialHprepPitrilysin Metalloproteinase 1Metalloprotease 1Hmp1 |
| Database Links | Reactome: R-HSA-1268020 |
| Cellular Localisation | MitochondrionMitochondrion Matrix |
| Alternative Protein Names | Presequence Protease - Mitochondrial proteinHprep proteinPitrilysin Metalloproteinase 1 proteinMetalloprotease 1 proteinHmp1 proteinPITRM1 proteinKIAA1104 proteinMP1 proteinPREP protein |
Information sourced from Uniprot.org