Human PIP4K2B/PIP4KII-beta protein (Recombinant) (N-His) (STJP009974)
SPECIFICATIONS
HostE.coli
ImmunogenHomo sapiens (Human)
General Information
| Short Description | Recombinant-Human PIP4K2B/PIP4KII-beta-N-His protein was developed from e.coli for the region N-His. For use in research applications. |
| Applications | ELISA/Immunogen/SDS-PAGE/WB |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Dilution Range | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| Formulation | Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol. |
| Storage Instruction | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt. |
Target Information
| Gene Symbol | PIP4K2B |
| Gene ID | 8396 |
| Uniprot ID | PI42B_HUMAN |
| Immunogen | Homo sapiens (Human) |
| Immunogen Region | Ser2-Thr416 |
Additional Info
| Post Translational Modifications | Ubiquitinated by the SPOP/CUL3 complex. Ubiquitination is stimulated by PtdIns5P levels. Phosphorylated on serine residues. |
| Function | Participates in the biosynthesis of phosphatidylinositol 4,5-bisphosphate. Preferentially utilizes GTP, rather than ATP, for PI(5)P phosphorylation and its activity reflects changes in direct proportion to the physiological GTP concentration. Its GTP-sensing activity is critical for metabolic adaptation. PIP4Ks negatively regulate insulin signaling through a catalytic-independent mechanism. They interact with PIP5Ks and suppress PIP5K-mediated PtdIns(4,5)P2 synthesis and insulin-dependent conversion to PtdIns(3,4,5)P3. |
| Protein Name | Phosphatidylinositol 5-Phosphate 4-Kinase Type-2 Beta1-Phosphatidylinositol 5-Phosphate 4-Kinase 2-BetaDiphosphoinositide Kinase 2-BetaPhosphatidylinositol 5-Phosphate 4-Kinase Type Ii BetaPi(5p 4-Kinase Type Ii BetaPip4kii-BetaPtdins(5p-4-Kinase Isoform 2-Beta |
| Database Links | Reactome: R-HSA-1660499Reactome: R-HSA-6811555Reactome: R-HSA-6811558Reactome: R-HSA-8847453 |
| Cellular Localisation | Endoplasmic Reticulum MembranePeripheral Membrane ProteinCell MembraneNucleusCytoplasmAssociated With The Plasma Membrane And The Endoplasmic Reticulum |
| Alternative Protein Names | Phosphatidylinositol 5-Phosphate 4-Kinase Type-2 Beta protein1-Phosphatidylinositol 5-Phosphate 4-Kinase 2-Beta proteinDiphosphoinositide Kinase 2-Beta proteinPhosphatidylinositol 5-Phosphate 4-Kinase Type Ii Beta proteinPi(5p 4-Kinase Type Ii Beta proteinPip4kii-Beta proteinPtdins(5p-4-Kinase Isoform 2-Beta proteinPIP4K2B proteinPIP5K2B protein |
Information sourced from Uniprot.org