Human PINX1 protein (Recombinant) (N-His-SUMO & C-Strep) (STJP007640)

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STJP007640
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Host: E. coli
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Recombinant-Human PINX1-N-His-SUMO & C-Strep protein was developed from e. coli and has a target region of N-His-SUMO & C-Strep. For use in research applications.
Formulation: Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Storage Instruction: Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt.
Gene Symbol: PINX1
Gene ID: 54984
Uniprot ID: PINX1_HUMAN
Immunogen Region: Asn72-Lys149
Immunogen: Homo sapiens (Human)
Post Translational Modifications Cleaved by enterovirus protease 3C to promote apoptosis.
Function Microtubule-binding protein essential for faithful chromosome segregation. Mediates TRF1 and TERT accumulation in nucleolus and enhances TRF1 binding to telomeres. Inhibits telomerase activity. May inhibit cell proliferation and act as tumor suppressor.
Protein Name Pin2/Terf1-Interacting Telomerase Inhibitor 1
Liver-Related Putative Tumor Suppressor
Pin2-Interacting Protein X1
Protein 67-11-3
Trf1-Interacting Protein 1
Cellular Localisation Nucleus
Nucleolus
Chromosome
Telomere
Centromere
Kinetochore
Localizes In Nucleoli
At Telomere Speckles And To The Outer Plate Of Kinetochores
Localization To The Kinetochore Is Mediated By Its Central Region And Depends On Ndc80 And Cenpe
Alternative Protein Names Pin2/Terf1-Interacting Telomerase Inhibitor 1 protein
Liver-Related Putative Tumor Suppressor protein
Pin2-Interacting Protein X1 protein
Protein 67-11-3 protein
Trf1-Interacting Protein 1 protein
PINX1 protein
LPTL protein
LPTS protein

Information sourced from Uniprot.org

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