Human PIN4 protein (Recombinant) (N-His) (STJP006230)

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STJP006230
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Host: E. coli
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Recombinant-Human PIN4-N-His protein was developed from e. coli and has a target region of N-His. For use in research applications.
Formulation: Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Storage Instruction: Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt.
Gene Symbol: PIN4
Gene ID: 5303
Uniprot ID: PIN4_HUMAN
Immunogen Region: Ser23-Arg130
Immunogen: Homo sapiens (Human)
Post Translational Modifications Phosphorylated. Isoform 1 phosphorylation occurs both in the nucleus and the cytoplasm. Isoform 1 phosphorylation at Ser-19 does not affect its PPIase activity but is required for nuclear localization, and the dephosphorylation is a prerequisite for the binding to DNA. The unphosphorylated isoform 1 associates with the pre-rRNP complexes in the nucleus. Isoform 2 is sumoylated with SUMO2 and SUMO3.
Function Isoform 1 is involved as a ribosomal RNA processing factor in ribosome biogenesis. Binds to tightly bent AT-rich stretches of double-stranded DNA. Isoform 2 binds to double-stranded DNA.
Protein Name Peptidyl-Prolyl Cis-Trans Isomerase Nima-Interacting 4
Parvulin-14
Par14
Hpar14
Parvulin-17
Par17
Hpar17
Peptidyl-Prolyl Cis-Trans Isomerase Pin4
Ppiase Pin4
Peptidyl-Prolyl Cis/Trans Isomerase Epvh
Hepvh
Rotamase Pin4
Cellular Localisation Isoform 1: Nucleus
Nucleolus
Cytoplasm
Cytoskeleton
Spindle
Colocalizes In The Nucleolus During Interphase And On The Spindle Apparatus During Mitosis With Npm1
Isoform 2: Mitochondrion
Mitochondrion Matrix
Imported In A Time- And Membrane Potential-Dependent Manner To The Mitochondrial Matrix
But Without Concomitant Processing Of The Protein
Directed To Mitochondria By A Novel N-Terminal Domain That Functions As A Non-Cleavable Mitochondrial Targeting Peptide
Alternative Protein Names Peptidyl-Prolyl Cis-Trans Isomerase Nima-Interacting 4 protein
Parvulin-14 protein
Par14 protein
Hpar14 protein
Parvulin-17 protein
Par17 protein
Hpar17 protein
Peptidyl-Prolyl Cis-Trans Isomerase Pin4 protein
Ppiase Pin4 protein
Peptidyl-Prolyl Cis/Trans Isomerase Epvh protein
Hepvh protein
Rotamase Pin4 protein
PIN4 protein

Information sourced from Uniprot.org

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