Human PIK3AP1 protein (Recombinant) (N-His) (STJP005614)
SPECIFICATIONS
HostE.coli
ImmunogenHomo sapiens (Human)
General Information
| Short Description | Recombinant-Human PIK3AP1-N-His protein was developed from e.coli for the region N-His. For use in research applications. |
| Applications | ELISA/Immunogen/SDS-PAGE/WB |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Dilution Range | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| Formulation | Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol. |
| Storage Instruction | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt. |
Target Information
| Gene Symbol | PIK3AP1 |
| Gene ID | 118788 |
| Uniprot ID | BCAP_HUMAN |
| Immunogen | Homo sapiens (Human) |
| Immunogen Region | Leu489-Ser730 |
Additional Info
| Post Translational Modifications | Constitutively phosphorylated. Phosphorylated on tyrosine residues in C-terminal region by ABL1. Phosphorylated on tyrosine residues within the YXXM motifs by BTK and SYK. Isoform 1 and isoform 2 are phosphorylated on tyrosine residues, most likely within the YXXM motifs, via CD19 activation. Toll-like receptor activation induces appearance of a phosphorylated form associated with membranes. |
| Function | Signaling adapter that contributes to B-cell development by linking B-cell receptor (BCR) signaling to the phosphoinositide 3-kinase (PI3K)-Akt signaling pathway. Has a complementary role to the BCR coreceptor CD19, coupling BCR and PI3K activation by providing a docking site for the PI3K subunit PIK3R1. Alternatively, links Toll-like receptor (TLR) signaling to PI3K activation, a process preventing excessive inflammatory cytokine production. Also involved in the activation of PI3K in natural killer cells. May be involved in the survival of mature B-cells via activation of REL. |
| Protein Name | Phosphoinositide 3-Kinase Adapter Protein 1B-Cell Adapter For Phosphoinositide 3-KinaseB-Cell Phosphoinositide 3-Kinase Adapter Protein 1 |
| Database Links | Reactome: R-HSA-1257604Reactome: R-HSA-2219530Reactome: R-HSA-6811558Reactome: R-HSA-983695 |
| Cellular Localisation | CytoplasmCell MembranePeripheral Membrane Protein |
| Alternative Protein Names | Phosphoinositide 3-Kinase Adapter Protein 1 proteinB-Cell Adapter For Phosphoinositide 3-Kinase proteinB-Cell Phosphoinositide 3-Kinase Adapter Protein 1 proteinPIK3AP1 proteinBCAP protein |
Information sourced from Uniprot.org